{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["Rajora MA"],"funding":["Natural Sciences and Engineering Research Council of Canada","Princess Margaret Cancer Foundation","Terry Fox Research Institute","Peterborough K. M. Hunter Charitable Foundation","McLaughlin Centre, University of Toronto","Prostate Cancer Canada","Canada Foundation for Innovation","Canadian Institutes of Health Research","Institute of Cancer Research","Canada Research Chairs","CIHR"],"pubmed_abstract":["Microbubble-enabled focused ultrasound (MB-FUS) has revolutionized nano and molecular drug delivery capabilities. Yet, the absence of longitudinal, systematic, quantitative studies of microbubble shell pharmacokinetics hinders progress within the MB-FUS field. Microbubble radiolabeling challenges contribute to this void. This barrier is overcome by developing a one-pot, purification-free copper chelation protocol able to stably radiolabel diverse porphyrin-lipid-containing Definity® analogues (pDefs) with >95% efficiency while maintaining microbubble physicochemical properties. Five tri-modal (ultrasound-, positron emission tomography (PET)-, and fluorescent-active) [<sup>64</sup> Cu]Cu-pDefs are created with varying lipid acyl chain length and charge, representing the most prevalently stu"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pagination":["e2304453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10811482"],"repository":["biostudies-literature"],"pubmed_title":["Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate."],"pmcid":["PMC10811482"],"pubmed_authors":["Dhaliwal A","Goertz D","Pellow C","Chen J","Zheng M","Choi V","Zheng G","Rajora MA","Overchuk M","Lou JWH"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate.","description":"Microbubble-enabled focused ultrasound (MB-FUS) has revolutionized nano and molecular drug delivery capabilities. Yet, the absence of longitudinal, systematic, quantitative studies of microbubble shell pharmacokinetics hinders progress within the MB-FUS field. Microbubble radiolabeling challenges contribute to this void. This barrier is overcome by developing a one-pot, purification-free copper chelation protocol able to stably radiolabel diverse porphyrin-lipid-containing Definity® analogues (pDefs) with >95% efficiency while maintaining microbubble physicochemical properties. Five tri-modal (ultrasound-, positron emission tomography (PET)-, and fluorescent-active) [<sup>64</sup> Cu]Cu-pDefs are created with varying lipid acyl chain length and charge, representing the most prevalently stu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T09:17:54.134Z","creation":"2025-04-04T09:17:54.134Z"},"accession":"S-EPMC10811482","cross_references":{"pubmed":["38032129"],"doi":["10.1002/advs.202304453"]}}