biostudies-literatureUnknown16(2)Abdalla TSA<h4>Background</h4>Patient selection for lymphadenectomy remains a controversial aspect in the treatment of pancreatic neuroendocrine tumors (pNETs), given the growing importance of parenchyma-sparing resections and minimally invasive procedures.<h4>Methods</h4>This population-based analysis was derived from the German Cancer Registry Group during the period from 2000 to 2021. Patients with upfront resected non-functional non-metastatic pNETs were included.<h4>Results</h4>Out of 5520 patients with pNET, 1006 patients met the inclusion criteria. Fifty-three percent of the patients were male. The median age was 64 ± 17 years. G1, G2, and G3 pNETs were found in 57%, 37%, and 7% of the patients, respectively. Lymph node metastasis (LNM) was present in 253 (24%) of all patients. LNM was an indeCancers440https://www.ebi.ac.uk/biostudies/studies/S-EPMC10814740biostudies-literatureWhen Should Lymphadenectomy Be Performed in Non-Metastatic Pancreatic Neuroendocrine Tumors? A Population-Based Analysis of the German Clinical Cancer Registry Group.PMC10814740Litkevych SDeichmann SBronsert PWellner UFAbdalla TSABraun RZeissig SRKeck TBolm LGebauer JKleihues van Tol KKlinkhammer-Schalke MHummel RHonselmann KCfalseWhen Should Lymphadenectomy Be Performed in Non-Metastatic Pancreatic Neuroendocrine Tumors? A Population-Based Analysis of the German Clinical Cancer Registry Group.<h4>Background</h4>Patient selection for lymphadenectomy remains a controversial aspect in the treatment of pancreatic neuroendocrine tumors (pNETs), given the growing importance of parenchyma-sparing resections and minimally invasive procedures.<h4>Methods</h4>This population-based analysis was derived from the German Cancer Registry Group during the period from 2000 to 2021. Patients with upfront resected non-functional non-metastatic pNETs were included.<h4>Results</h4>Out of 5520 patients with pNET, 1006 patients met the inclusion criteria. Fifty-three percent of the patients were male. The median age was 64 ± 17 years. G1, G2, and G3 pNETs were found in 57%, 37%, and 7% of the patients, respectively. Lymph node metastasis (LNM) was present in 253 (24%) of all patients. LNM was an inde2024-01-01T00:00:00Z2024 Jan2025-04-21T15:53:51.014Z2025-04-21T15:53:51.014ZS-EPMC108147403827588210.3390/cancers16020440