{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Gal Etzioni TR"],"pubmed_abstract":["Invasive fungal infections (IFI) cause morbidity and mortality in children with acute leukemia (AL). We retrospectively collected data on febrile neutropenic episodes (FNE) in AL children (2016-2021) and assessed factors associated with proven/probable IFI. Ninety-three children developed 339 FNE. Seventeen (18.3%) children developed 19 proven/probable IFI (11 yeast; eight molds). The proven/probable yeast IFI rate was 6/52 (11.5%) in children who belong to the high risk for IFI category (HR-IFI-AL: high-risk acute lymphocytic leukemia (ALL), acute myeloid leukemia, relapse); and 5/41 (12.2%) in the non-HR-IFI-AL category (standard/intermediate risk ALL). The proven/probable mold IFI rate was 7/52 (13.5%) in HR-IFI-AL children and 1/41 (2.4%) in the non-HR-IFI-AL category. In the multivari"],"journal":["Microorganisms"],"pagination":["145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10820110"],"repository":["biostudies-literature"],"pubmed_title":["Invasive Fungal Infections in Children with Acute Leukemia: Epidemiology, Risk Factors, and Outcome."],"pmcid":["PMC10820110"],"pubmed_authors":["Korem M","Gal Etzioni TR","Nitzan-Luques A","Temper V","Averbuch D","Goldstein G","Fainshtain N","Weinreb S"],"additional_accession":[]},"is_claimable":false,"name":"Invasive Fungal Infections in Children with Acute Leukemia: Epidemiology, Risk Factors, and Outcome.","description":"Invasive fungal infections (IFI) cause morbidity and mortality in children with acute leukemia (AL). We retrospectively collected data on febrile neutropenic episodes (FNE) in AL children (2016-2021) and assessed factors associated with proven/probable IFI. Ninety-three children developed 339 FNE. Seventeen (18.3%) children developed 19 proven/probable IFI (11 yeast; eight molds). The proven/probable yeast IFI rate was 6/52 (11.5%) in children who belong to the high risk for IFI category (HR-IFI-AL: high-risk acute lymphocytic leukemia (ALL), acute myeloid leukemia, relapse); and 5/41 (12.2%) in the non-HR-IFI-AL category (standard/intermediate risk ALL). The proven/probable mold IFI rate was 7/52 (13.5%) in HR-IFI-AL children and 1/41 (2.4%) in the non-HR-IFI-AL category. In the multivari","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-21T15:56:14.073Z","creation":"2025-04-21T15:56:14.073Z"},"accession":"S-EPMC10820110","cross_references":{"pubmed":["38257971"],"doi":["10.3390/microorganisms12010145"]}}