biostudies-literatureUnknown12(1)Gal Etzioni TRInvasive fungal infections (IFI) cause morbidity and mortality in children with acute leukemia (AL). We retrospectively collected data on febrile neutropenic episodes (FNE) in AL children (2016-2021) and assessed factors associated with proven/probable IFI. Ninety-three children developed 339 FNE. Seventeen (18.3%) children developed 19 proven/probable IFI (11 yeast; eight molds). The proven/probable yeast IFI rate was 6/52 (11.5%) in children who belong to the high risk for IFI category (HR-IFI-AL: high-risk acute lymphocytic leukemia (ALL), acute myeloid leukemia, relapse); and 5/41 (12.2%) in the non-HR-IFI-AL category (standard/intermediate risk ALL). The proven/probable mold IFI rate was 7/52 (13.5%) in HR-IFI-AL children and 1/41 (2.4%) in the non-HR-IFI-AL category. In the multivariMicroorganisms145https://www.ebi.ac.uk/biostudies/studies/S-EPMC10820110biostudies-literatureInvasive Fungal Infections in Children with Acute Leukemia: Epidemiology, Risk Factors, and Outcome.PMC10820110Korem MGal Etzioni TRNitzan-Luques ATemper VAverbuch DGoldstein GFainshtain NWeinreb SfalseInvasive Fungal Infections in Children with Acute Leukemia: Epidemiology, Risk Factors, and Outcome.Invasive fungal infections (IFI) cause morbidity and mortality in children with acute leukemia (AL). We retrospectively collected data on febrile neutropenic episodes (FNE) in AL children (2016-2021) and assessed factors associated with proven/probable IFI. Ninety-three children developed 339 FNE. Seventeen (18.3%) children developed 19 proven/probable IFI (11 yeast; eight molds). The proven/probable yeast IFI rate was 6/52 (11.5%) in children who belong to the high risk for IFI category (HR-IFI-AL: high-risk acute lymphocytic leukemia (ALL), acute myeloid leukemia, relapse); and 5/41 (12.2%) in the non-HR-IFI-AL category (standard/intermediate risk ALL). The proven/probable mold IFI rate was 7/52 (13.5%) in HR-IFI-AL children and 1/41 (2.4%) in the non-HR-IFI-AL category. In the multivari2024-01-01T00:00:00Z2024 Jan2025-04-21T15:56:14.073Z2025-04-21T15:56:14.073ZS-EPMC108201103825797110.3390/microorganisms12010145