{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marzucco A"],"funding":["the European Union-NextGenerationEU through the Italian Ministry of University and Research under PNRR-Mission 4 Component 2, Investment 3.3 \"Partnerships extended to universities, re-search centres","Monica Cricca"],"pagination":["153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10820201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<i>Candida</i> spp. are an important opportunistic pathogen that can represent a possible cause of severe infections, especially in immunocompromised individuals. The clinical impact of <i>Candida</i> spp. depends, in part, on the ability to form biofilms, communities of nestled cells into the extracellular matrix. In this study, we compared the biofilm formation ability of 83 strains of <i>Candida</i> spp. isolated from blood cultures and other materials, such as respiratory samples, urine, and exudate, and their sensitivity to fluconazole (FLZ). Strains were divided into tertiles to establish cut-offs to classify isolates as low, moderate, or high biofilm producers (<0.26, 0.266-0.839, >0.839) and biofilms with low, moderate, or high metabolic activity (<0.053, 0.053-0.183, >0.183). A no"],"journal":["Microorganisms"],"pubmed_title":["Evaluation of Biofilm Production and Antifungal Susceptibility to Fluconazole in Clinical Isolates of <i>Candida</i> spp. in Both Planktonic and Biofilm Form."],"pmcid":["PMC10820201"],"funding_grant_id":["Ricerca Fondamentale Orientata (RFO) 2021 and 2022","352/2021 - CUP J33C22001330009"],"pubmed_authors":["Tamburini MV","Congestri F","Brandolini M","Taddei F","Colosimo C","Montanari MS","Dirani G","Sambri V","Zannoli S","Schiavone P","Gatti G","Fantini M","Morotti M","Manera M","Cricca M","Arfilli V","Grumiro L","De Pascali AM","Marzucco A","Denicolo A"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Biofilm Production and Antifungal Susceptibility to Fluconazole in Clinical Isolates of <i>Candida</i> spp. in Both Planktonic and Biofilm Form.","description":"<i>Candida</i> spp. are an important opportunistic pathogen that can represent a possible cause of severe infections, especially in immunocompromised individuals. The clinical impact of <i>Candida</i> spp. depends, in part, on the ability to form biofilms, communities of nestled cells into the extracellular matrix. In this study, we compared the biofilm formation ability of 83 strains of <i>Candida</i> spp. isolated from blood cultures and other materials, such as respiratory samples, urine, and exudate, and their sensitivity to fluconazole (FLZ). Strains were divided into tertiles to establish cut-offs to classify isolates as low, moderate, or high biofilm producers (<0.26, 0.266-0.839, >0.839) and biofilms with low, moderate, or high metabolic activity (<0.053, 0.053-0.183, >0.183). A no","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T09:16:59.013Z","creation":"2025-04-04T09:16:59.013Z"},"accession":"S-EPMC10820201","cross_references":{"pubmed":["38257980"],"doi":["10.3390/microorganisms12010153"]}}