{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Eckert D"],"pubmed_abstract":["Musculoskeletal disorders (MSDs) are associated with pain and lead to reduced mobility and quality of life for patients. Radon therapy is used as alternative or complementary to pharmaceutical treatments. According to previous reports, radon spa leads to analgesic and anti-inflammatory effects, but the cellular and molecular mechanisms are widely unknown. A previous study (RAD-ON01) revealed, that bone erosion markers like collagen fragments (C-terminal telopeptide, CTX) are reduced after radon spa treatment in serum of patients with degenerative MSDs. Within the scope of the prospective, placebo-controlled RAD-ON02 trial presented here, we analyzed the influence of radon and thermal spa treatment on osteoclastogenesis. From patient blood, we isolate monocytes, seeded them on bone slices a"],"journal":["Frontiers in immunology"],"pagination":["1284609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10824901"],"repository":["biostudies-literature"],"pubmed_title":["Osteo-immunological impact of radon spa treatment: due to radon or spa alone? Results from the prospective, thermal bath placebo-controlled RAD-ON02 trial."],"pmcid":["PMC10824901"],"pubmed_authors":["Schang J","Dorrschuck L","Donaubauer AJ","Evic M","Isbruch M","Eckert D","Er M","Gaipl US","Frey B","Fournier C","Rapp F"],"additional_accession":[]},"is_claimable":false,"name":"Osteo-immunological impact of radon spa treatment: due to radon or spa alone? Results from the prospective, thermal bath placebo-controlled RAD-ON02 trial.","description":"Musculoskeletal disorders (MSDs) are associated with pain and lead to reduced mobility and quality of life for patients. Radon therapy is used as alternative or complementary to pharmaceutical treatments. According to previous reports, radon spa leads to analgesic and anti-inflammatory effects, but the cellular and molecular mechanisms are widely unknown. A previous study (RAD-ON01) revealed, that bone erosion markers like collagen fragments (C-terminal telopeptide, CTX) are reduced after radon spa treatment in serum of patients with degenerative MSDs. Within the scope of the prospective, placebo-controlled RAD-ON02 trial presented here, we analyzed the influence of radon and thermal spa treatment on osteoclastogenesis. From patient blood, we isolate monocytes, seeded them on bone slices a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-07-14T22:50:20.235Z","creation":"2025-06-01T01:56:19.499Z"},"accession":"S-EPMC10824901","cross_references":{"pubmed":["38292488"],"doi":["10.3389/fimmu.2023.1284609"]}}