{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41"],"submitter":["Gao Y"],"pubmed_abstract":["ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains unclear. In the present study, bioinformatic analyses of The Cancer Genome Atlas (TCGA) data were performed, and the association of ALKBH5 in predicting overall survival in patients with ICC was investigated. Then, the clinical data of patients from The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University (Changzhou, China) was used to reveal the overall survival of patients with ICC with different ALKBH5 expression levels by Kaplan-Meier survival analysis. Subsequently, in vitro and in vivo studies were conducted to explore"],"journal":["Translational oncology"],"pagination":["101858"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10825528"],"repository":["biostudies-literature"],"pubmed_title":["m<sup>6</sup>A demethylase ALKBH5 maintains stemness of intrahepatic cholangiocarcinoma by sustaining BUB1B expression and cell proliferation."],"pmcid":["PMC10825528"],"pubmed_authors":["Liu Y","Liu Z","Li Y","Yu M","Tang L","Gao Y","Qin X","Kong Z","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"m<sup>6</sup>A demethylase ALKBH5 maintains stemness of intrahepatic cholangiocarcinoma by sustaining BUB1B expression and cell proliferation.","description":"ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains unclear. In the present study, bioinformatic analyses of The Cancer Genome Atlas (TCGA) data were performed, and the association of ALKBH5 in predicting overall survival in patients with ICC was investigated. Then, the clinical data of patients from The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University (Changzhou, China) was used to reveal the overall survival of patients with ICC with different ALKBH5 expression levels by Kaplan-Meier survival analysis. Subsequently, in vitro and in vivo studies were conducted to explore","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-28T03:18:48.026Z","creation":"2025-04-21T15:50:11.407Z"},"accession":"S-EPMC10825528","cross_references":{"pubmed":["38242006"],"doi":["10.1016/j.tranon.2023.101858"]}}