{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petroll WM"],"funding":["NEI NIH HHS","National Institutes of Health"],"pagination":["109523"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10825899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["233"],"pubmed_abstract":["Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze c"],"journal":["Experimental eye research"],"pubmed_title":["The impact of UV cross-linking on corneal stromal cell migration, differentiation and patterning."],"pmcid":["PMC10825899"],"funding_grant_id":["R01 EY013322","T35 EY026510","P30 EY030413"],"pubmed_authors":["Hassaniardekani H","Sunkara Y","Petroll WM","Ikebe HR","Miron-Mendoza M","Sripathi NR"],"additional_accession":[]},"is_claimable":false,"name":"The impact of UV cross-linking on corneal stromal cell migration, differentiation and patterning.","description":"Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-04T10:13:11.568Z","creation":"2025-04-04T10:13:11.568Z"},"accession":"S-EPMC10825899","cross_references":{"pubmed":["37271309"],"doi":["10.1016/j.exer.2023.109523"]}}