{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Aparicio C"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents.<h4>Methods</h4>Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged ≤21 years with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses.<h4>Results</h4>Among 10"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.01.17.24301452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10827273"],"repository":["biostudies-literature"],"pubmed_title":["Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis."],"pmcid":["PMC10827273"],"funding_grant_id":["R01 AI123204","OT2 HL161847","TL1 TR001864","K23 AI159518"],"pubmed_authors":["Bio LL","James SH","Maron GM","Anosike BI","Nakamura MM","Oliveira CR","Willis ZI","Little C","Wolf J","Sue PK","Miller C","Singh P","Aparicio C"],"additional_accession":[]},"is_claimable":false,"name":"Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.","description":"<h4>Background</h4>Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents.<h4>Methods</h4>Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged ≤21 years with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses.<h4>Results</h4>Among 10","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-04-08T06:00:54.729Z","creation":"2025-04-05T13:57:15.369Z"},"accession":"S-EPMC10827273","cross_references":{"pubmed":["38293040"],"doi":["10.1101/2024.01.17.24301452"]}}