{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Q"],"funding":["NIA NIH HHS","Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province","Science and Technology Innovation 2030 Major Projects","NCI NIH HHS"],"pagination":["1407-1420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10828178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(1)"],"pubmed_abstract":["Amyloid-β (Aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (CU) to dementia due to Alzheimer's disease (AD), according to the diagnosis framework from the US National Institute on Aging and the Alzheimer's Association (NIA-AA). However, it is clinically difficult to predict those subjects who were already with Aβ positive (A +) or tau positive (T +). As a typical characteristic of neurodegeneration in the diagnosis framework, the hypometabolism of the posterior cingulate cortex (PCC) has significant clinical value in the early prediction and prevention of AD. In this paper, we proposed the glucose metabolism in the PCC as a biomarker supplement to Aβ and tau biomarkers. First, we calculated the standard uptake value ratio (SUVR) of PCC based on flu"],"journal":["GeroScience"],"pubmed_title":["Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of <sup>18</sup>F-FDG-PET."],"pmcid":["PMC10828178"],"funding_grant_id":["P30 AG072977","P30 AG072972","P01 CA095616","U01 AG024904","P30 AG066514","R01 CA094143","2022ZD0211606","P30 AG066518","HYX21004"],"pubmed_authors":["Massoglia D","Crawford K","Belden CM","Taylor JL","Grossman H","Brewer J","Rosen HJ","James O","Lane B","Chertkow H","DeCarli C","Gunter J","Leon S","Figurski M","Lord JL","Kendall T","Montine T","Villanueva-Meyer J","Wolk D","Taylor-Reinwald L","Petrella JR","Mathis C","Rachinsky I","Woo E","Frank R","Roberson E","Geldmacher D","Duara R","Watkins F","Reeder S","Grafman J","de Leon MJ","Oates E","Celmins D","Doraiswamy P","Wu CK","Morrison R","Pawluczyk S","Jiminez G","Fletcher E","Lah JJ","DeVous M","Raichle M","Munic D","Salloway S","Peskind ER","Karlawish JH","Mintun MA","Turner RS","Capote H","Neu S","Feldman H","Khachaturian Z","Jones D","Dang M","Johnson KA","Lee TY","Bernick C","Preda A","Asthana S","Fan C","Aisen P","Hosein C","Ott BR","Burns JM","Holtzman D","Brockington J","MacAvoy MG","Quinn J","Chaing G","Smith CD","Mintzer J","Snyder P","Hsiao J","Roberts P","Trojanowski JQ","Swerdlow RH","Tremont G","Paul S","Borowski B","Landau S","Fargher K","Davis M","Koeppe RA","Varon D","McAdams-Ortiz C","Sorensen G","Hunt C","Jicha G","Raudin L","Carter R","Reynolds B","Kowall N","Green RC","Reiman EM","Finley S","Li G","Chen K","Brand C","Petrie EC","Bell KL","Kitzmiller TJ","Teodoro L","Sirrel SA","Jacobson SA","Carlsson CM","Zimmerman EA","Pomara N","Fleisher A","Li T","Sadowsky C","Friedl K","Anderson HS","Nho K","Porsteinsson AP","Tingus K","Jiang J","Miller BL","Johnson K","Hsiung GR","Johnson N","Hayes J","Schuff N","Johnson S","Diaz-Arrastia R","Rusinek H","Martinez W","Kertesz A","Honig LS","Shah RC","Lerner A","Morris J","Fillit H","Kerwin D","Schultz SK","Lind B","Villena T","Johnson H","Bachman D","Jagust W","Saykin AJ","Mason SS","Heidebrink JL","Gessert D","Rosen A","Scharre DW","Albert M","Anderson K","Potkin SG","Faber K","Apostolova L","Thompson P","Albers CS","Kittur S","Schwartz ES","Vemuri P","Petersen R","Shen L","Oliver A","Budson AE","Clark D","Zhang Q","Tinklenberg J","Senjem M","Onyike C","Vanderswag H","Thal L","Martin K","Furst AJ","Sather T","Fleischman D","Silverman DHS","Frey M","Spann BM","Stern Y","Greig MT","Bartzokis G","Fruehling J","Kaye J","Hefti F","Bartha R","Mitsis E","Norbash A","Trost D","Davies P","Conrad G","Walter S","Kielb S","Knopman D","Adeli A","Bernstein M","Killiany R","Yesavage JA","Neylan T","Kataki M","Cairns NJ","Quiceno M","Drost D","Oakley M","Arfanakis K","Han Y","Buckholtz N","Toga AW","Galvin JE","D'Agostino D","Santulli RB","Sabbagh MN","Hake AM","Foroud TM","Schneider S","Beccera M","Weiner M","Sarrael A","Blank K","Kim S","Relkin N","Arnold SE","Sperling RA","Carson RE","Householder E","Lee V","Hudson L","Rainka M","Smith KE","Pearlson GD","Farlow MR","Mudge B","Beckett L","Carroll M","Jack CR","Herring S","Lopez OL","Mesulam MM","Lipowski K","Graff-Radford NR","Dolen S","Wang L","Wang M","Foster N","Ogrocki P","van Dyck CH","Querfurth H","Ponto LLB","Hernando R","Mulnard RA","Malloy P","Griffith R","Bates V","Lu PH","Garg P","Marson D","Wong TZ","Sinha P","Glodzik L","Weiner MW","Potter W","Simpson DM","de Toledo-Morrell L","Williamson JD","Korecka M","Kuller L","Harvey D","Ward C","De Santi S","Correia S","Womack K","Hardy P","Martin-Cook K","Michel CA","Ismail M","Mathews D","Carmichae O","Cerbone B","Matthews BR","Ances B","Shim H","Doody RS","Chowdhury M","Alzheimer’s Disease Neuroimaging Initiative","Brown AD","Borrie M","Bergman H","Olichney J","Rogers J","Thai G","Harding S","Schwartz A","Makino KM","King R","Cellar JS","Schneider LS","Spicer K","Levey AI","Pasternak S","Smith A","Marshall G","Parfitt F","Donohue M","Johnson PL","Raj BA","Rountree S","Nguyen D","Allard J","Assaly M","Tariot P","Goldstein BS","Shaw LM","Sink KM","Thomas RG","Kantarci K"],"additional_accession":[]},"is_claimable":false,"name":"Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of <sup>18</sup>F-FDG-PET.","description":"Amyloid-β (Aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (CU) to dementia due to Alzheimer's disease (AD), according to the diagnosis framework from the US National Institute on Aging and the Alzheimer's Association (NIA-AA). However, it is clinically difficult to predict those subjects who were already with Aβ positive (A +) or tau positive (T +). As a typical characteristic of neurodegeneration in the diagnosis framework, the hypometabolism of the posterior cingulate cortex (PCC) has significant clinical value in the early prediction and prevention of AD. In this paper, we proposed the glucose metabolism in the PCC as a biomarker supplement to Aβ and tau biomarkers. First, we calculated the standard uptake value ratio (SUVR) of PCC based on flu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-27T03:23:50.518Z","creation":"2025-04-06T13:26:05.671Z"},"accession":"S-EPMC10828178","cross_references":{"pubmed":["37610594"],"doi":["10.1007/s11357-023-00897-0"]}}