biostudies-literatureHamilton HLNational Institute of Neurological Disorders and StrokeNINDS NIH HHSNCI NIH HHSNIH HHS1607-1625https://www.ebi.ac.uk/biostudies/studies/S-EPMC10828232biostudies-literatureUnknown46(2)Alzheimer's disease (AD), the most common cause of dementia in the elderly, is characterized by the accumulation of intracellular neurofibrillary tangles, extracellular amyloid plaques, and neuroinflammation. In partnership with microglial cells, astrocytes are key players in the regulation of neuroinflammation. Fatty acid binding protein 7 (FABP7) belongs to a family of conserved proteins that regulate lipid metabolism, energy homeostasis, and inflammation. FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system. We observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25-35 (Aβ_25-35) induces FABP7 upregulation. In addition, FABP7 expression is upregulated in the brain of APP/PS1 micGeroScienceFABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.PMC10828232R01NS122973S10 OD023526P30 CA014520R01 NS122973Balmer GKinscherf NAPehar MVargas MRSalamat SMBresque MHamilton HLfalseFABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.Alzheimer's disease (AD), the most common cause of dementia in the elderly, is characterized by the accumulation of intracellular neurofibrillary tangles, extracellular amyloid plaques, and neuroinflammation. In partnership with microglial cells, astrocytes are key players in the regulation of neuroinflammation. Fatty acid binding protein 7 (FABP7) belongs to a family of conserved proteins that regulate lipid metabolism, energy homeostasis, and inflammation. FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system. We observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25-35 (Aβ_25-35) induces FABP7 upregulation. In addition, FABP7 expression is upregulated in the brain of APP/PS1 mic2024-01-01T00:00:00Z2024 Apr2026-06-02T11:22:58.724Z2025-04-05T12:46:39.226ZS-EPMC108282323768865610.1007/s11357-023-00916-0