biostudies-literatureGuo Dthe National Key Research and Development Program of Ministry of Chinathe Shanghai Sailing ProgramNational Natural Science Foundation of Chinauhad258https://www.ebi.ac.uk/biostudies/studies/S-EPMC10828779biostudies-literatureUnknown11(1)<i>Scutellaria baicalensis</i> Georgi, also known as huang-qin in traditional Chinese medicine, is a widely used herbal remedy due to its anticancer, antivirus, and hepatoprotective properties. The <i>S. baicalensis</i> genome was sequenced many years ago; by contrast, the proteome as the executer of most biological processes of <i>S. baicalensis</i> in the aerial parts, as well as the secondary structure of the roots (xylem, phloem, and periderm), is far less comprehensively characterized. Here we attempt to depict the molecular landscape of the non-model plant <i>S. baicalensis</i> through a multi-omics approach, with the goal of constructing a highly informative and valuable reference dataset. Furthermore, we provide an in-depth characterization dissection to explain the two distinct flHorticulture researchMulti-omics landscape to decrypt the distinct flavonoid biosynthesis of <i>Scutellaria baicalensis</i> across multiple tissues.PMC108287792022YFC270460382104328, 81973291, 8212206620YF1458900Xia ZZhu ZFeng FJia XGuo DLv DChen XWang ZHan TCao QfalseMulti-omics landscape to decrypt the distinct flavonoid biosynthesis of <i>Scutellaria baicalensis</i> across multiple tissues.<i>Scutellaria baicalensis</i> Georgi, also known as huang-qin in traditional Chinese medicine, is a widely used herbal remedy due to its anticancer, antivirus, and hepatoprotective properties. The <i>S. baicalensis</i> genome was sequenced many years ago; by contrast, the proteome as the executer of most biological processes of <i>S. baicalensis</i> in the aerial parts, as well as the secondary structure of the roots (xylem, phloem, and periderm), is far less comprehensively characterized. Here we attempt to depict the molecular landscape of the non-model plant <i>S. baicalensis</i> through a multi-omics approach, with the goal of constructing a highly informative and valuable reference dataset. Furthermore, we provide an in-depth characterization dissection to explain the two distinct fl2024-01-01T00:00:00Z2024 Jan2026-04-24T03:20:18.51Z2025-04-07T07:22:15.446ZS-EPMC108287793829889910.1093/hr/uhad258