{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(5)"],"submitter":["Wang B"],"pubmed_abstract":["Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe<sub>3</sub>O<sub>4</sub>@mSiO<sub>2</sub> nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically a"],"journal":["Science advances"],"pagination":["eadk8970"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10830105"],"repository":["biostudies-literature"],"pubmed_title":["tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments."],"pmcid":["PMC10830105"],"pubmed_authors":["Yang H","Du S","Wang B","Ji F","Chiu PWY","Jiang S","Chan KF","Leung TWH","Yu SCH","Zhang L","Qiu M","Ko H","Wang Q","Zhang Z","Ip BYM","Chung JPW","Ning Z","Han J","Sung JJY"],"additional_accession":[]},"is_claimable":false,"name":"tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments.","description":"Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe<sub>3</sub>O<sub>4</sub>@mSiO<sub>2</sub> nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-14T23:15:20.054Z","creation":"2025-05-18T11:10:55.441Z"},"accession":"S-EPMC10830105","cross_references":{"pubmed":["38295172"],"doi":["10.1126/sciadv.adk8970"]}}