biostudies-literatureUnknown10(5)Wang BMicro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe₃O₄@mSiO₂ nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically aScience advanceseadk8970https://www.ebi.ac.uk/biostudies/studies/S-EPMC10830105biostudies-literaturetPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments.PMC10830105Yang HDu SWang BJi FChiu PWYJiang SChan KFLeung TWHYu SCHZhang LQiu MKo HWang QZhang ZIp BYMChung JPWNing ZHan JSung JJYfalsetPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments.Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe₃O₄@mSiO₂ nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically a2024-01-01T00:00:00Z2024 Feb2026-07-14T23:15:20.054Z2025-05-18T11:10:55.441ZS-EPMC108301053829517210.1126/sciadv.adk8970