biostudies-literatureUnknown15(1)Brockway MMHuman milk (HM) contains macronutrients, micronutrients, and a multitude of other bioactive factors, which can have a long-term impact on infant growth and development. We systematically searched MEDLINE, EMBASE, Cochrane Library, Scopus, and Web of Science to synthesize evidence published between 1980 and 2022 on HM components and anthropometry through 2 y of age among term-born infants. From 9992 abstracts screened, 141 articles were included and categorized based on their reporting of HM micronutrients, macronutrients, or bioactive components. Bioactives including hormones, HM oligosaccharides (HMOs), and immunomodulatory components are reported here, based on 75 articles from 69 unique studies reporting observations from 9980 dyads. Research designs, milk collection strategies, samplinAdvances in nutrition (Bethesda, Md.)100127https://www.ebi.ac.uk/biostudies/studies/S-EPMC10831900biostudies-literatureHuman Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review.PMC10831900Musse SRefvik RRodriguez NGranger MMcDermid JMSidhu KKMonnin CAllen LHLotoski LHampel DChan DGeddes DTJehan FKolsteren PBode LAzad MBReyes SMDaniel AIEriksen KGPatel PPBrockway MMGauglitz JMfalseHuman Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review.Human milk (HM) contains macronutrients, micronutrients, and a multitude of other bioactive factors, which can have a long-term impact on infant growth and development. We systematically searched MEDLINE, EMBASE, Cochrane Library, Scopus, and Web of Science to synthesize evidence published between 1980 and 2022 on HM components and anthropometry through 2 y of age among term-born infants. From 9992 abstracts screened, 141 articles were included and categorized based on their reporting of HM micronutrients, macronutrients, or bioactive components. Bioactives including hormones, HM oligosaccharides (HMOs), and immunomodulatory components are reported here, based on 75 articles from 69 unique studies reporting observations from 9980 dyads. Research designs, milk collection strategies, samplin2024-01-01T00:00:00Z2024 Jan2026-07-15T01:57:47.722Z2025-04-04T19:22:23.546ZS-EPMC108319003780221410.1016/j.advnut.2023.09.015