{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Natural Science Foundation of China","Soochow University Extracurricular Academic"],"pagination":["327-338"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10834191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["<h4>Background</h4>Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays a significant role in glucose metabolism and is highly expressed in various tumors. However, its role in lung adenocarcinoma (LUAD) remains incompletely understood.<h4>Methods</h4>Through bioinformatic analysis, we identified a positive association between high expression of TPI1 and metastasis in LUAD. Western blot, RT-qPCR, wound healing assays and transwell experiments, were employed to investigate potential mechanisms.<h4>Results</h4>In this study, bioinformatic analysis showed that high expression of TPI1 was associated with poor prognosis in LUAD patients. We examined the expression of TPI1 in 29 paired LUAD tissues and found that TPI1 expression was higher in LUAD tissues than in pai"],"journal":["Thoracic cancer"],"pubmed_title":["TPI1 promotes MAPK/ERK-induced EMT, cell migration and invasion in lung adenocarcinoma."],"pmcid":["PMC10834191"],"funding_grant_id":["KY2023016Z","81873417"],"pubmed_authors":["Zhang F","Li Y","Li C","Jia X","Pan B","Zhu X","Tong X","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"TPI1 promotes MAPK/ERK-induced EMT, cell migration and invasion in lung adenocarcinoma.","description":"<h4>Background</h4>Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays a significant role in glucose metabolism and is highly expressed in various tumors. However, its role in lung adenocarcinoma (LUAD) remains incompletely understood.<h4>Methods</h4>Through bioinformatic analysis, we identified a positive association between high expression of TPI1 and metastasis in LUAD. Western blot, RT-qPCR, wound healing assays and transwell experiments, were employed to investigate potential mechanisms.<h4>Results</h4>In this study, bioinformatic analysis showed that high expression of TPI1 was associated with poor prognosis in LUAD patients. We examined the expression of TPI1 in 29 paired LUAD tissues and found that TPI1 expression was higher in LUAD tissues than in pai","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-04-16T03:21:34.845Z","creation":"2025-04-06T13:49:13.47Z"},"accession":"S-EPMC10834191","cross_references":{"pubmed":["38130074"],"doi":["10.1111/1759-7714.15196"]}}