biostudies-literatureAuvin SNational Institute of Neurological Disorders and StrokeEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentConsejo Nacional de Ciencia y TecnologíaNICHD NIH HHSDeutsche ForschungsgemeinschaftUniversity College LondonNINDS NIH HHSInstitut Universitaire de FranceDefense Human Resources ActivityAmerican Epilepsy Society2891-2908https://www.ebi.ac.uk/biostudies/studies/S-EPMC10836613biostudies-literatureUnknown64(11)Despite progress in the development of anti-seizure medications (ASMs), one third of people with epilepsy have drug-resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 2010, helped identify individuals who might benefit from presurgical evaluation early on. As the incidence of DRE remains high, the TASK1 workgroup on DRE of the ILAE/American Epilepsy Society (AES) Joint Translational Task Force discussed the heterogeneity and complexity of its presentation and mechanisms, the confounders in drawing mechanistic insights when testing treatment responses, and barriers in modeling DRE across the lifespan and translating across species. We propose that it is necessary to revisit the current definition of DRE, in order to transform the preclinical and clinical research of mechanisms and biomarkers, to identify novel, effective, precise, pharmacologic treatments, allowing for earlier recognition of drug resistance and individualized therapies.EpilepsiaRevisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force.PMC10836613R37 NS043209A3‐S‐26782W81XWH‐22‐1‐0510U54 NS100064PO 681/12‐1NS43209W81XWH‐22‐1‐0210P50 HD105352R01 NS043209R01 NS127524Auvin SGalanopoulou ASTASK1 workgroup on drug-resistant epilepsy of the ILAE/AES Joint Translational Task ForceRocha LMoshe SLPotschka HWalker MCfalseRevisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force.Despite progress in the development of anti-seizure medications (ASMs), one third of people with epilepsy have drug-resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 2010, helped identify individuals who might benefit from presurgical evaluation early on. As the incidence of DRE remains high, the TASK1 workgroup on DRE of the ILAE/American Epilepsy Society (AES) Joint Translational Task Force discussed the heterogeneity and complexity of its presentation and mechanisms, the confounders in drawing mechanistic insights when testing treatment responses, and barriers in modeling DRE across the lifespan and translating across species. We propose that it is necessary to revisit the current definition of DRE, in order to transform the preclinical and clinical research of mechanisms and biomarkers, to identify novel, effective, precise, pharmacologic treatments, allowing for earlier recognition of drug resistance and individualized therapies.2023-01-01T00:00:00Z2023 Nov2025-04-04T02:25:05.581Z2025-04-04T02:25:05.581ZS-EPMC108366133767671910.1111/epi.17751