{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen B"],"funding":["Society of Clinical Child and Adolescent Psychology","NIMH NIH HHS","American Psychological Association","National Institutes of Health","Autism Speaks Royal Arch Mason Predoctoral Fellowship","NIH HHS"],"pagination":["bhae005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10839841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(2)"],"pubmed_abstract":["While disruptions in brain maturation in the first years of life in ASD are well documented, little is known about how the brain structure and function are related in young children with ASD compared to typically developing peers. We applied a multivariate pattern analysis to examine the covariation patterns between brain morphometry and local brain spontaneous activity in 38 toddlers and preschoolers with ASD and 31 typically developing children using T1-weighted structural MRI and resting-state fMRI data acquired during natural sleep. The results revealed significantly reduced brain structure-function correlations in ASD. The resultant brain structure and function composite indices were associated with age among typically developing children, but not among those with ASD, suggesting mistiming of typical brain maturational trajectories early in life in autism. Additionally, the brain function composite indices were associated with the overall developmental and adaptive behavior skills in the ASD group, highlighting the neurodevelopmental significance of early local brain activity in autism."],"journal":["Cerebral cortex (New York, N.Y. : 1991)"],"pubmed_title":["Reduced covariation between brain morphometry and local spontaneous activity in young children with ASD."],"pmcid":["PMC10839841"],"funding_grant_id":["R01 MH107802"],"pubmed_authors":["Olson L","Salmina M","Rios A","Linke A","Chen B","Fishman I"],"additional_accession":[]},"is_claimable":false,"name":"Reduced covariation between brain morphometry and local spontaneous activity in young children with ASD.","description":"While disruptions in brain maturation in the first years of life in ASD are well documented, little is known about how the brain structure and function are related in young children with ASD compared to typically developing peers. We applied a multivariate pattern analysis to examine the covariation patterns between brain morphometry and local brain spontaneous activity in 38 toddlers and preschoolers with ASD and 31 typically developing children using T1-weighted structural MRI and resting-state fMRI data acquired during natural sleep. The results revealed significantly reduced brain structure-function correlations in ASD. The resultant brain structure and function composite indices were associated with age among typically developing children, but not among those with ASD, suggesting mistiming of typical brain maturational trajectories early in life in autism. Additionally, the brain function composite indices were associated with the overall developmental and adaptive behavior skills in the ASD group, highlighting the neurodevelopmental significance of early local brain activity in autism.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T02:09:46.661Z","creation":"2025-04-04T02:09:46.661Z"},"accession":"S-EPMC10839841","cross_references":{"pubmed":["38282456"],"doi":["10.1093/cercor/bhae005"]}}