{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Freiherr Von Seckendorff A"],"pubmed_abstract":["<h4>Background</h4>Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear.<h4>Objectives</h4>Our objective was to determine whether <i>Porphyromonas gingivalis</i> (Pg), a periodontal bacterium, could be detected within thrombus aspirates, modify thrombus composition, and endovascular therapy responses.<h4>Methods</h4>The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining. Thrombus blood cell composition according to gingipain status was analyzed in a subset of 63 patients.<h4>Results</h4>Pg gingipain immunostaining was positive in 33.7% of thrombi (95% CI, 26.7%-40.8%). The p"],"journal":["Research and practice in thrombosis and haemostasis"],"pagination":["102313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10840352"],"repository":["biostudies-literature"],"pubmed_title":["Periodontitis in ischemic stroke: impact of <i>Porphyromonas gingivalis</i> on thrombus composition and ischemic stroke outcomes."],"pmcid":["PMC10840352"],"pubmed_authors":["Ho-Tin-Noe B","Desilles JP","Labreuche J","Di Meglio L","Delbosc S","compoCLOT study group","Boursin P","Nomenjanahary MS","Freiherr Von Seckendorff A","Brun A","Ollivier V","Brikci-Nigassa N","Piotin M","Mazighi M","Dupont S","Hamdani M"],"additional_accession":[]},"is_claimable":false,"name":"Periodontitis in ischemic stroke: impact of <i>Porphyromonas gingivalis</i> on thrombus composition and ischemic stroke outcomes.","description":"<h4>Background</h4>Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear.<h4>Objectives</h4>Our objective was to determine whether <i>Porphyromonas gingivalis</i> (Pg), a periodontal bacterium, could be detected within thrombus aspirates, modify thrombus composition, and endovascular therapy responses.<h4>Methods</h4>The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining. Thrombus blood cell composition according to gingipain status was analyzed in a subset of 63 patients.<h4>Results</h4>Pg gingipain immunostaining was positive in 33.7% of thrombi (95% CI, 26.7%-40.8%). The p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-03T17:22:06.662Z","creation":"2025-04-06T10:43:14.664Z"},"accession":"S-EPMC10840352","cross_references":{"pubmed":["38318152"],"doi":["10.1016/j.rpth.2023.102313"]}}