{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tejeda M"],"funding":["NIA NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","Dutch Research Council (NWO)","NHGRI NIH HHS","NINDS NIH HHS","National Institutes of Health","Wellcome Trust","NIH HHS","National Institute on Aging"],"pagination":["253-265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10840621"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Introduction</h4>Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer's disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls.<h4>Methods</h4>DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets.<h4>Results</h4>Several viruses were significant predictors of AD according to the machine learning classifiers. Subsequent regression analyses showed that herpes simplex type 1 (HSV-1) (odds ratio [OR] = 3.71, p = 8.03 × 10-4) a"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["DNA from multiple viral species is associated with Alzheimer's disease risk."],"pmcid":["PMC10840621"],"funding_grant_id":["RC2 HL102419","U01 AG062943","U19 AG024904","R01 AG009956","047.017.043","R01 AG019085","R37 AG015473","R01‐AG076002","U54 HG003079","P20 AG068053","U01 HL096902","HHSN268201100009I","R01 AG023629","P30 AG066444","R01 AG048927","P01 NS026630","HHSN268201100009C","R01 AG027944","R01 AG057909","P30 AG072958","P30 AG072959","RF1 AG058066","U54 HG003067","P30 AG066546","HHSN268200800007C","R01 AG032289","N01 HC055222","P30 AG038072","340755","R01 AG019757","RF1 AG054074","RC2 HG005605","U01 AG032984","U24 AG041689","P50 NS039764","P30 AG072946","P30 AG072947","R56 AG051876","U19 AG066567","P30 AG010133","R01 AG060747","U01 HL080295","R01 AG032990","N01 HC025195","U24 AG021886","P30 AG072931","P20 AG068077","R01 AG041797","R01 AG033040","U01AG049506","U01AG049507","R01 AG020098","U01 NS041588","R01 AG076002","R01 AG054076","R01 NS017950","911-03-012","R01 AG044829","RF1 AG051504","U01 AG068057","R01 AG011380","R01 AG049607","P30 AG066530","P50 AG016574","P20 AG068082","RF1 AG054052","R01 AG048234","U24 AG056270","R01 AG025259","R01 AG017917","U01 AG058654","R01 HL105756","R01 AG061155","U01 HL130114","R01 AG054047","N01 HC085083","N01 HC085082","N01 HC085081","P30 AG062677","N01 HC085086","R01 NS029993","U54 HG003273","P30 AG066514","P50 AG008012","P30 AG066515","U01 AG046139","N01 HC085080","P30 AG066518","P30 AG066519","P30 AG062715","HHSN268201100005C","P50 NS071674","R01 AG046949","R01 HL070825","HHSN268201100005I","R01 AG042188","HHSN268201100005G","U19 AG068753","R01 AG015928","U54 AG052427","HHSN268201500001C","P30 AG062421","P30 AG062422","P30 AG010161","R01 AG031272","RF1 AG058267","U01 AG052409","P30 AG066506","P30 AG066507","P30 AG062429","P30 AG066508","P30 AG066509","HHSN268201100006C","P30 AG066511","P30 AG066512","U24 AG072122","R01 NS080820","U01 AG058635","HHSN268201500001I","U01 AG052411","P20 AG068024","HHSN268201100010C","U01 AG052410","R01 AG028786","R01 AG015819","R01 AG059716","UF1 AG047133","U01 AG062602","175.010.200","HHSN268201100011I","RC4 AG039085","U01 HL096917","R01-AG076002","U01 AG006781","R01 AG018016","R01 AG021547","P30 AG072975","P30 AG066462","P30 AG072976","P30 AG072977","RF1 AG054023","U24 AG074855","HHSN268201200036C","HHSN268201100007C","RF1 AG027161","P30 AG072972","U01 AG057659","P30 AG066468","P30 AG072973","HHSN268201100011C","P30 AG072978","R01 NS069719","R01 AG079280","P30 AG072979","U01 AG058589","HHSN268201100007I","R01 AG009029","RF1 AG015473","P50 AG005136","R01 AG011101","P50 AG005133","U01 HL096814","HHSN268201100008C","RF1 AG057519","U01 HL096899","R01 AG021136","R01 AG033193","U01 AG049505","U01 AG049506","U01 AG049507","U01 HL096812","U01 AG049508","N01 HC085079","K23 AG030944","R01 AG042210","HHSN268201100008I","HHSN268201100012C"],"pubmed_authors":["Tejeda M","Wang LS","Martin ER","Lunetta KL","Schellenberg GD","Farrell J","Wetzler L","Haines JL","Zhu C","Pericak-Vance MA","Bush WS","Farrer LA","Sherva R"],"additional_accession":[]},"is_claimable":false,"name":"DNA from multiple viral species is associated with Alzheimer's disease risk.","description":"<h4>Introduction</h4>Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer's disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls.<h4>Methods</h4>DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets.<h4>Results</h4>Several viruses were significant predictors of AD according to the machine learning classifiers. Subsequent regression analyses showed that herpes simplex type 1 (HSV-1) (odds ratio [OR] = 3.71, p = 8.03 × 10-4) a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-04-30T14:36:32.105Z","creation":"2026-04-07T16:03:31.623Z"},"accession":"S-EPMC10840621","cross_references":{"pubmed":["37578203"],"doi":["10.1002/alz.13414"]}}