{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["MacColl Garfinkel A"],"funding":["NSF","NICHD NIH HHS","NCATS NIH HHS","NIA NIH HHS","NIDDK NIH HHS","NIDCD NIH HHS","NHLBI NIH HHS","NINDS NIH HHS","National Institutes of Health","NIGMS NIH HHS","Biotechnology and Biological Sciences Research Council","National Science Foundation"],"pagination":["2597-2613.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10840693"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(22)"],"pubmed_abstract":["An instructive role for metabolism in embryonic patterning is emerging, although a role for mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the Spemann-Mangold Organizer, via hypoxia-inducible factor 1α (Hif-1α) in Xenopus. Hypoxia or decoupling ATP production from oxygen consumption expands the Organizer by activating Hif-1α. In addition, oxygen consumption is 20% higher in the Organizer than in the ventral mesoderm, indicating an elevation in mitochondrial respiration. To reconcile increased mitochondrial respiration with activation of Hif-1α, we discovered that the \"free\" c-subunit ring of the F<sub>1</sub>F<sub>o</sub> ATP synthase creates an inner mitochondrial membrane leak, which decouples ATP produc"],"journal":["Developmental cell"],"pubmed_title":["Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus."],"pmcid":["PMC10840693"],"funding_grant_id":["T32DK007058","R01GM148490","K01AG054734","UL1 TR001863","R01NS112706","R01 NS112706","F31 HL140823","RF1AG072484","BB/W018284/1","F31HL140823","R01 NS099124","R01 HL149746","R01HD102186","K01 AG054734","R37 NS045876","R01 GM148490","R21 DC019948","DGE-1762114","R01 HD114493","R01 AG072484","T32GM007270","R37NS045876","RF1 AG072484","T32 DK007058","R01NS099124","R01 NS045876","T32 GM007270","R01 HD102186"],"pubmed_authors":["Alavian KN","Wills AE","Smith PJS","MacColl Garfinkel A","Patel JH","Shteyman A","Jonas EA","Mnatsakanyan N","Khokha MK"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus.","description":"An instructive role for metabolism in embryonic patterning is emerging, although a role for mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the Spemann-Mangold Organizer, via hypoxia-inducible factor 1α (Hif-1α) in Xenopus. Hypoxia or decoupling ATP production from oxygen consumption expands the Organizer by activating Hif-1α. In addition, oxygen consumption is 20% higher in the Organizer than in the ventral mesoderm, indicating an elevation in mitochondrial respiration. To reconcile increased mitochondrial respiration with activation of Hif-1α, we discovered that the \"free\" c-subunit ring of the F<sub>1</sub>F<sub>o</sub> ATP synthase creates an inner mitochondrial membrane leak, which decouples ATP produc","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-01T20:28:14.019Z","creation":"2025-04-05T19:59:05.004Z"},"accession":"S-EPMC10840693","cross_references":{"pubmed":["37673063"],"doi":["10.1016/j.devcel.2023.08.015"]}}