biostudies-literatureSaltiel NNational Institute of Neurological Disorders and StrokeBLRD VANCATS NIH HHSNIA NIH HHSU.S. Department of DefenseNINDS NIH HHSConcussion Legacy FoundationAndlinger Family FoundationU.S. Department of Veterans AffairsNational Institute on Aging314-324https://www.ebi.ac.uk/biostudies/studies/S-EPMC10842014biostudies-literatureUnknown95(2)<h4>Objective</h4>Exposure to repetitive head impacts (RHI) is associated with later-life cognitive symptoms and neuropathologies, including chronic traumatic encephalopathy (CTE). Cognitive decline in community cohorts is often due to multiple pathologies; however, the frequency and contributions of these pathologies to cognitive impairment in people exposed to RHI are unknown. Here, we examined the relative contributions of 13 neuropathologies to cognitive symptoms and dementia in RHI-exposed brain donors.<h4>Methods</h4>Neuropathologists examined brain tissue from 571 RHI-exposed donors and assessed for the presence of 13 neuropathologies, including CTE, Alzheimer disease (AD), Lewy body disease (LBD), and transactive response DNA-binding protein 43 (TDP-43) inclusions. Cognitive statusAnnals of neurologyRelative Contributions of Mixed Pathologies to Cognitive and Functional Symptoms in Brain Donors Exposed to Repetitive Head Impacts.PMC10842014PRARP #13267017U01NS086659U54NS115266RF1AG054156K23NS102399UL1 TR001430R01 AG075876RF1AG057768I01BX005933RF1 NS122854I01 BX005933RF1 AG057902K23AG046377RF1 AG054156RF1 AG062348K23 NS102399U54 NS115266R01 AG062348U19AG068753P30 AG072978P30AG072978I01 BX005161Mez JNair ESaltiel NMcKee ACAlosco MLHuber BNowinski CBaucom ZAbdolmohammadi BOlaniyan ADwyer BAlvarez VEPalmisano JNStern RAMartin BUretsky MStein TDMenzin TShah ASchneider JABoyle PACantu RCTripodis YNicks RDaneshvar DHYhang EKatz DIfalseRelative Contributions of Mixed Pathologies to Cognitive and Functional Symptoms in Brain Donors Exposed to Repetitive Head Impacts.<h4>Objective</h4>Exposure to repetitive head impacts (RHI) is associated with later-life cognitive symptoms and neuropathologies, including chronic traumatic encephalopathy (CTE). Cognitive decline in community cohorts is often due to multiple pathologies; however, the frequency and contributions of these pathologies to cognitive impairment in people exposed to RHI are unknown. Here, we examined the relative contributions of 13 neuropathologies to cognitive symptoms and dementia in RHI-exposed brain donors.<h4>Methods</h4>Neuropathologists examined brain tissue from 571 RHI-exposed donors and assessed for the presence of 13 neuropathologies, including CTE, Alzheimer disease (AD), Lewy body disease (LBD), and transactive response DNA-binding protein 43 (TDP-43) inclusions. Cognitive status2024-01-01T00:00:00Z2024 Feb2025-04-21T23:55:19.826Z2025-04-05T19:20:28.121ZS-EPMC108420143792104210.1002/ana.26823