{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Khalil H"],"pubmed_abstract":["<h4>Aim</h4>suppression of methylation inhibitors (epigenetic genes) in hepatocarcinogenesis induced by diethylnitrosamine using glycyrrhetinic acid.<h4>Method</h4>In the current work, we investigated the effect of sole GA combined with different agents such as doxorubicin (DOX) or probiotic bacteria (<i>Lactobacillus rhamanosus</i>) against hepatocarcinogenesis induced by diethylnitrosamine to improve efficiency. The genomic DNA was isolated from rats' liver tissues to evaluate either methylation-sensitive or methylation-dependent resection enzymes. The methylation activity of the targeting genes DLC-1, TET-1, NF-kB, and STAT-3 was examined using specific primers and cleaved DNA products. Furthermore, flow cytometry was used to determine the protein expression profiles of DLC-1 and TET-1 "],"journal":["Frontiers in immunology"],"pagination":["1206990"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10844948"],"repository":["biostudies-literature"],"pubmed_title":["Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine."],"pmcid":["PMC10844948"],"pubmed_authors":["Ibrahim IA","Hassan A","Elmaksoud AIA","Mohamed DD","Khalil H","Rijo P","Mahrous H","Al-Salmi FA","Nada AH"],"additional_accession":[]},"is_claimable":false,"name":"Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine.","description":"<h4>Aim</h4>suppression of methylation inhibitors (epigenetic genes) in hepatocarcinogenesis induced by diethylnitrosamine using glycyrrhetinic acid.<h4>Method</h4>In the current work, we investigated the effect of sole GA combined with different agents such as doxorubicin (DOX) or probiotic bacteria (<i>Lactobacillus rhamanosus</i>) against hepatocarcinogenesis induced by diethylnitrosamine to improve efficiency. The genomic DNA was isolated from rats' liver tissues to evaluate either methylation-sensitive or methylation-dependent resection enzymes. The methylation activity of the targeting genes DLC-1, TET-1, NF-kB, and STAT-3 was examined using specific primers and cleaved DNA products. Furthermore, flow cytometry was used to determine the protein expression profiles of DLC-1 and TET-1 ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-22T03:25:31.765Z","creation":"2025-04-05T20:40:25.456Z"},"accession":"S-EPMC10844948","cross_references":{"pubmed":["38322013"],"doi":["10.3389/fimmu.2023.1206990"]}}