biostudies-literatureVine JNCCIH NIH HHSNational Center for Complementary and Integrative HealthNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS41https://www.ebi.ac.uk/biostudies/studies/S-EPMC10845751biostudies-literatureUnknown28(1)<h4>Background</h4>This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.<h4>Methods</h4>Patient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (NCT03550794) were combined in this analysis. The primary outcome for the current study was survival without the receipt of renal replacement therapy (RRT). Analyses were performed on the overall cohort and the thiamine-deficient cohort (thiamine < 8 nmol/L).<h4>Results</h4>Totally, 158 patients were included. Overall, thiamine administration was associated with higher odds of being alive and RRT-free (adjusted odds ratio [aOR]: 2.05 [95% confidence interval (CI) 1.08-3.90]) and not needing RRT (aOR: 2.59 [95% CI 1.01-6.62]). In the thiamine-deficient group, thiamine administration was associated with higher odds of being alive and RRT-free (aOR: 8.17 [95% CI 1.79-37.22]) and surviving to hospital discharge (aOR: 6.84 [95% CI 1.54-30.36]). There was a significant effect modification by baseline thiamine deficiency for alive and RRT-free (interaction, p = 0.016) and surviving to hospital discharge (p = 0.019).<h4>Conclusion</h4>In the combined analysis of two previous randomized trials, thiamine administration was associated with higher odds of being alive and RRT-free at hospital discharge in patients with septic shock. This signal was stronger in patients with thiamine deficiency.Critical care (London, England)Thiamine administration in septic shock: a post hoc analysis of two randomized trials.PMC10845751T32 HL155020K24 HL127101K23GM128005R21AT005119K24HL127101K23 GM128005R21 AT005119T32HL155020Balaji LLeland SBMoskowitz ADonnino MWKravitz MSGrossestreuer AVBerlin NVine JLee JHfalseThiamine administration in septic shock: a post hoc analysis of two randomized trials.<h4>Background</h4>This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.<h4>Methods</h4>Patient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (NCT03550794) were combined in this analysis. The primary outcome for the current study was survival without the receipt of renal replacement therapy (RRT). Analyses were performed on the overall cohort and the thiamine-deficient cohort (thiamine < 8 nmol/L).<h4>Results</h4>Totally, 158 patients were included. Overall, thiamine administration was associated with higher odds of being alive and RRT-free (adjusted odds ratio [aOR]: 2.05 [95% confidence interval (CI) 1.08-3.90]) and not needing RRT (aOR: 2.59 [95% CI 1.01-6.62]). In the thiamine-deficient group, thiamine administration was associated with higher odds of being alive and RRT-free (aOR: 8.17 [95% CI 1.79-37.22]) and surviving to hospital discharge (aOR: 6.84 [95% CI 1.54-30.36]). There was a significant effect modification by baseline thiamine deficiency for alive and RRT-free (interaction, p = 0.016) and surviving to hospital discharge (p = 0.019).<h4>Conclusion</h4>In the combined analysis of two previous randomized trials, thiamine administration was associated with higher odds of being alive and RRT-free at hospital discharge in patients with septic shock. This signal was stronger in patients with thiamine deficiency.2024-01-01T00:00:00Z2024 Feb2026-06-30T03:09:56.918Z2025-04-04T14:38:12.168ZS-EPMC108457513832152910.1186/s13054-024-04818-1