biostudies-literatureUnknown16Jin T<h4>Background</h4>Due to the complex histological type and anatomical structures, there has been considerable debate on the classification of adenocarcinoma of the esophagogastric junction (AEG), especially Siewert II AEG. Furthermore, neither the American Joint Committee on Cancer (AJCC) 7th tumor-node-metastasis (TNM) [esophageal adenocarcinoma (E) or gastric cancer (G)] nor the AJCC 8th TNM (E or G) accurately predicted the prognosis of patients with Siewert II AEG.<h4>Objective</h4>This study aimed to investigate the factors influencing the survival and prognosis of patients with Siewert II AEG and establish a new and better prognostic predictive model.<h4>Design</h4>A retrospective study.<h4>Methods</h4>Patients with Siewert II AEG, retrieved from the Surveillance, Epidemiology, and Therapeutic advances in medical oncology17588359241229425https://www.ebi.ac.uk/biostudies/studies/S-EPMC10846006biostudies-literatureDevelopment and validation of a nomogram for Siewert II esophagogastric junction adenocarcinoma: a retrospective analysis.PMC10846006Li ZDHe FJChen ZWYang KJin TLiang PPHu JKChen ZHfalseDevelopment and validation of a nomogram for Siewert II esophagogastric junction adenocarcinoma: a retrospective analysis.<h4>Background</h4>Due to the complex histological type and anatomical structures, there has been considerable debate on the classification of adenocarcinoma of the esophagogastric junction (AEG), especially Siewert II AEG. Furthermore, neither the American Joint Committee on Cancer (AJCC) 7th tumor-node-metastasis (TNM) [esophageal adenocarcinoma (E) or gastric cancer (G)] nor the AJCC 8th TNM (E or G) accurately predicted the prognosis of patients with Siewert II AEG.<h4>Objective</h4>This study aimed to investigate the factors influencing the survival and prognosis of patients with Siewert II AEG and establish a new and better prognostic predictive model.<h4>Design</h4>A retrospective study.<h4>Methods</h4>Patients with Siewert II AEG, retrieved from the Surveillance, Epidemiology, and 2024-01-01T00:00:00Z20242025-04-22T03:20:37.954Z2025-04-05T20:44:00.124ZS-EPMC108460063832275310.1177/17588359241229425