{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang H"],"funding":["MOST | National Natural Science Foundation of China (NSFC)","MOST | National Natural Science Foundation of China"],"pagination":["e0325623"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10846271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["Bacteria absorb different forms of iron through various channels to meet their needs. Our previous studies have shown that TseF, a type VI secretion system effector for Fe uptake, facilitates the delivery of outer membrane vesicle-associated <i>Pseudomonas</i> quinolone signal (PQS)-Fe<sup>3+</sup> to bacterial cells by a process involving the Fe(III) pyochelin receptor FptA and the porin OprF. However, the form in which the PQS-Fe<sup>3+</sup> complex enters the periplasm and how it is moved into the cytoplasm remain unclear. Here, we first demonstrate that the PQS-Fe<sup>3+</sup> complex enters the cell directly through FptA or OprF. Next, we show that inner membrane transporters such as FptX, PchHI, and FepBCDG are not only necessary for <i>Pseudomonas aeruginosa</i> to absorb PQS-Fe<su"],"journal":["Microbiology spectrum"],"pubmed_title":["PQS and pyochelin in <i>Pseudomonas aeruginosa</i> share inner membrane transporters to mediate iron uptake."],"pmcid":["PMC10846271"],"funding_grant_id":["31700031, 32070103, 32360015, 31860012"],"pubmed_authors":["Yang J","Zhang H","Zeng J","Ma X","Lin J","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"PQS and pyochelin in <i>Pseudomonas aeruginosa</i> share inner membrane transporters to mediate iron uptake.","description":"Bacteria absorb different forms of iron through various channels to meet their needs. Our previous studies have shown that TseF, a type VI secretion system effector for Fe uptake, facilitates the delivery of outer membrane vesicle-associated <i>Pseudomonas</i> quinolone signal (PQS)-Fe<sup>3+</sup> to bacterial cells by a process involving the Fe(III) pyochelin receptor FptA and the porin OprF. However, the form in which the PQS-Fe<sup>3+</sup> complex enters the periplasm and how it is moved into the cytoplasm remain unclear. Here, we first demonstrate that the PQS-Fe<sup>3+</sup> complex enters the cell directly through FptA or OprF. Next, we show that inner membrane transporters such as FptX, PchHI, and FepBCDG are not only necessary for <i>Pseudomonas aeruginosa</i> to absorb PQS-Fe<su","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-22T03:21:52.928Z","creation":"2025-04-05T20:41:32.524Z"},"accession":"S-EPMC10846271","cross_references":{"pubmed":["38171001"],"doi":["10.1128/spectrum.03256-23"]}}