{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["He T"],"funding":["NCI NIH HHS"],"pubmed_abstract":["The POU2F3-POU2AF2/3 (OCA-T1/2) transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we found that the POU2F3 molecular subtype of SCLC (SCLC-P) exhibits an exquisite dependence on the activity of the mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complex. SCLC-P cell lines were sensitive to nanomolar levels of a mSWI/SNF ATPase proteolysis targeting chimera (PROTAC) degrader when compared to other molecular subtypes of SCLC. POU2F3 and its cofactors were found to interact with components of the mSWI/SNF complex. The POU2F3 transcription factor complex was evicted from chromatin upon mSWI/SNF ATPase degradation, leading to attenuation of downstream oncogenic signaling in SCLC-P cells."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.01.22.576669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10849552"],"repository":["biostudies-literature"],"pubmed_title":["Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies."],"pmcid":["PMC10849552"],"funding_grant_id":["R35 CA231996","P50 CA186786"],"pubmed_authors":["Young E","Ching-Yi Tien J","Samajdar S","Hou S","Kim N","Su F","Zheng H","Miner SJ","Mehra R","Wang X","Parolia A","Wu XS","Zheng Y","Mahapatra S","Abbineni C","Chinnaiyan AM","Eyunni S","Qiao Y","He T","Xiao L","Mannan R","Cao X","Klingbeil O","Vakoc CR","Ramachandra M"],"additional_accession":[]},"is_claimable":false,"name":"Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies.","description":"The POU2F3-POU2AF2/3 (OCA-T1/2) transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we found that the POU2F3 molecular subtype of SCLC (SCLC-P) exhibits an exquisite dependence on the activity of the mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complex. SCLC-P cell lines were sensitive to nanomolar levels of a mSWI/SNF ATPase proteolysis targeting chimera (PROTAC) degrader when compared to other molecular subtypes of SCLC. POU2F3 and its cofactors were found to interact with components of the mSWI/SNF complex. The POU2F3 transcription factor complex was evicted from chromatin upon mSWI/SNF ATPase degradation, leading to attenuation of downstream oncogenic signaling in SCLC-P cells.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T15:32:08.322Z","creation":"2025-04-19T21:08:20.639Z"},"accession":"S-EPMC10849552","cross_references":{"pubmed":["38328238"],"doi":["10.1101/2024.01.22.576669"]}}