{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59(2)"],"submitter":["Spyridonidis A"],"pubmed_abstract":["The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively)"],"journal":["Bone marrow transplantation"],"pagination":["217-223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10849946"],"repository":["biostudies-literature"],"pubmed_title":["Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation."],"pmcid":["PMC10849946"],"pubmed_authors":["Olesen G","Mohty M","Blau IW","Schroeder T","Wulf GG","Finke J","Bazarbachi A","Wagner-Drouet EM","Ciceri F","Maertens J","Stelljes M","Wilson KMO","de Latour RP","Spyridonidis A","Ganser A","Versluis J","Dreger P","Passweg J","Bourhis JH","Craddock C","Labopin M","Gedde-Dahl T","Potter V","Giebel S","Kroger N","Forcade E","Sengeloev H","Nagler A","Brissot E","Savani BP"],"additional_accession":[]},"is_claimable":false,"name":"Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation.","description":"The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively)","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-03T20:02:31.994Z","creation":"2025-04-04T14:38:20.436Z"},"accession":"S-EPMC10849946","cross_references":{"pubmed":["37978322"],"doi":["10.1038/s41409-023-02139-5"]}}