biostudies-literatureUnknown59(2)Spyridonidis AThe intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively)Bone marrow transplantation217-223https://www.ebi.ac.uk/biostudies/studies/S-EPMC10849946biostudies-literatureValidation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation.PMC10849946Olesen GMohty MBlau IWSchroeder TWulf GGFinke JBazarbachi AWagner-Drouet EMCiceri FMaertens JStelljes MWilson KMOde Latour RPSpyridonidis AGanser AVersluis JDreger PPassweg JBourhis JHCraddock CLabopin MGedde-Dahl TPotter VGiebel SKroger NForcade ESengeloev HNagler ABrissot ESavani BPfalseValidation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation.The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively)2024-01-01T00:00:00Z2024 Feb2026-06-03T20:02:31.994Z2025-04-04T14:38:20.436ZS-EPMC108499463797832210.1038/s41409-023-02139-5