{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["626(7998)"],"submitter":["Okubo T"],"pubmed_abstract":["Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos<sup>1-8</sup>. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation-stage studies. Thus, recent efforts have focused on developing in vitro self-organizing models using human stem cells<sup>9-17</sup>. Here, we report genetic and non-genetic approaches to generate authentic hypoblast cells (naive hPSC-derived hypoblast-like cells (nHyCs))-known to give rise to one of the two extraembryonic tissues essential for embryonic development-from naive human pluripotent stem cells (hPSCs). Our nHyCs spontaneously assemble with naive hPSCs to form a three-di"],"journal":["Nature"],"pagination":["357-366"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10849967"],"repository":["biostudies-literature"],"pubmed_title":["Hypoblast from human pluripotent stem cells regulates epiblast development."],"pmcid":["PMC10849967"],"pubmed_authors":["Woltjen K","Rivron N","Kishimoto K","Yamamoto T","Saitou M","Nakajima-Koyama M","Kabata M","Nakauchi H","Takashima Y","Masaki H","Okubo T","Sasaki E","Kaswandy B","Semi K","Sato H","Kunitomi H"],"additional_accession":[]},"is_claimable":false,"name":"Hypoblast from human pluripotent stem cells regulates epiblast development.","description":"Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos<sup>1-8</sup>. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation-stage studies. Thus, recent efforts have focused on developing in vitro self-organizing models using human stem cells<sup>9-17</sup>. Here, we report genetic and non-genetic approaches to generate authentic hypoblast cells (naive hPSC-derived hypoblast-like cells (nHyCs))-known to give rise to one of the two extraembryonic tissues essential for embryonic development-from naive human pluripotent stem cells (hPSCs). Our nHyCs spontaneously assemble with naive hPSCs to form a three-di","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-04-29T14:08:54.804Z","creation":"2025-02-18T23:14:02.593Z"},"accession":"S-EPMC10849967","cross_references":{"pubmed":["38052228"],"doi":["10.1038/s41586-023-06871-2"]}}