biostudies-literatureYou YAEwha Womans UniversityNational Institute of Health, Korea10565-10578https://www.ebi.ac.uk/biostudies/studies/S-EPMC10850187biostudies-literatureUnknown31(7)Maternal exposure to fine particulate matter (PM_2.5) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM_2.5 exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM_2.5 (˃15 ug/m³; n = 10) and Low PM_2.5 (≤ 15 ug/m³; n = 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (p-value < 0.05 and log2 fold change > 1Environmental science and pollution research internationalMaternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood.PMC108501872021-ER1208-01RP-Grant 2021Park MHSong JMKim MSLee SJKwon EKim YAPark SHur YMAPPO study groupBae JGKim YHNa SHKim YJYou YACho GJLee GIKim SMfalseMaternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood.Maternal exposure to fine particulate matter (PM_2.5) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM_2.5 exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM_2.5 (˃15 ug/m³; n = 10) and Low PM_2.5 (≤ 15 ug/m³; n = 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (p-value < 0.05 and log2 fold change > 12024-01-01T00:00:00Z2024 Feb2026-06-03T20:00:03.174Z2025-04-04T10:39:50.278ZS-EPMC108501873820018910.1007/s11356-023-31774-0