{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zecher BF"],"funding":["CCR NIH HHS","Bundesministerium für Bildung und Forschung","Frederick National Laboratory for Cancer Research","Deutsche Forschungsgemeinschaft","European Research Council","Landesforschungsförderung Hamburg","NCI NIH HHS","Daisy Hüet Roel Foundation","Academy of Medical Sciences"],"pagination":["325-337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10850656"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(2)"],"pubmed_abstract":["<h4>Objective</h4>Primary sclerosing cholangitis (PSC) is characterised by bile duct strictures and progressive liver disease, eventually requiring liver transplantation. Although the pathogenesis of PSC remains incompletely understood, strong associations with HLA-class II haplotypes have been described. As specific HLA-DP molecules can bind the activating NK-cell receptor NKp44, we investigated the role of HLA-DP/NKp44-interactions in PSC.<h4>Design</h4>Liver tissue, intrahepatic and peripheral blood lymphocytes of individuals with PSC and control individuals were characterised using flow cytometry, immunohistochemical and immunofluorescence analyses. HLA-DPA1 and HLA-DPB1 imputation and association analyses were performed in 3408 individuals with PSC and 34 213 controls. NK cell activat"],"journal":["Gut"],"pubmed_title":["&lt;i&gt;HLA-DPA1*02:01~B1*01:01&lt;/i&gt; is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells."],"pmcid":["PMC10850656"],"funding_grant_id":["N/A","HHSN261200800001E","HHSN261200800001C","CRU306 Primary sclerosing cholangitis","EXC 2167-390884018","EL 831/7-1 (project number 507145175)","LFF-FV78","SFB841/SP2","grant agreement n° 884830","01KI2110","884830","SGL020\\1037"],"pubmed_authors":["Farkkila M","Lazaridis KN","Fruh T","Haussinger D","Gores G","Hoelzemer A","International PSC Study Group (IPSCSG)","Huynh D","Schrumpf E","Martin MP","Schreiber S","Geier A","Anderson CA","Ytting H","Milkiewicz P","Hirschfield GM","Rorsman F","Muller LM","deValleVillalba MB","Shapiro D","Knuth A","Corpechot C","Lohse A","Trauner M","Altfeld M","Sauer P","Karlsen TH","Weersma RK","Marzioni M","Poch T","Manns ME","Lleo A","Ponsioen CY","Zweers S","Fabris L","Floreani A","Folseraas T","Burroughs A","Marschall HU","Levy C","Franke A","Keitel V","Jones D","Lindor K","Harley H","Bowlus CL","Schaap FG","Liu JZ","Cleynen I","Adams DH","Invernizzi P","Fickert P","Vermeire S","Kretschmer P","Vesterhaug M","Plentz R","Baumdick ME","Niersch J","Sandford RN","Juran BD","Black D","Sebode M","Lankisch T","Mulcahy HE","Liaskou E","Bjorkstrom N","Poupon R","Schumacher U","Kremer AE","Taylor-Robinson SD","Mammari SA","Eksteen B","Boberg KM","Brias S","Strazzabosco M","Razumilava N","Zecher BF","Burt A","Gotthardt D","Mullhaupt B","Schirmacher P","Wehmeyer MH","Zimmer V","Pereira S","Everson G","Aabakken L","Habermann R","Weismuller T","Oldhafer KJ","Chazouilleres O","Habior A","Webster G","Ueno Y","Chapman RW","Goldberg D","Ohira H","Beuers U","Merwe SV","Carrington M","Tanaka A","Straub BK","Khan SA","Mason A","Niehrs A","Melum E","Hov J","Schramm C","Kaser A","Alexander GJ","Pares A","Karpen SJ","Korner C","Steenbergen WV","Helmke S","Culver EL","Yuki Y","Almer S","Sauter G","Selmi C","Degenhardt F","Williamson K","Glow D","Fehse B","Talwalkar J","Padoan B","Mertens JC","Bjornsson E","Halilbasic E","Mells GF","Bergquist A","Ellinghaus E","Ellinghaus D","Danekas J","van Buuren HR","Schroder-Schwarz J","Shibolet O","Jansen PL","Lindstrom L","Fevery J","Schloer S","Wunsch E","Bunders MJ","Housset C","Rushbrook SM"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;HLA-DPA1*02:01~B1*01:01&lt;/i&gt; is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.","description":"<h4>Objective</h4>Primary sclerosing cholangitis (PSC) is characterised by bile duct strictures and progressive liver disease, eventually requiring liver transplantation. Although the pathogenesis of PSC remains incompletely understood, strong associations with HLA-class II haplotypes have been described. As specific HLA-DP molecules can bind the activating NK-cell receptor NKp44, we investigated the role of HLA-DP/NKp44-interactions in PSC.<h4>Design</h4>Liver tissue, intrahepatic and peripheral blood lymphocytes of individuals with PSC and control individuals were characterised using flow cytometry, immunohistochemical and immunofluorescence analyses. HLA-DPA1 and HLA-DPB1 imputation and association analyses were performed in 3408 individuals with PSC and 34 213 controls. NK cell activat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-12T05:48:16.156Z","creation":"2026-06-12T03:08:22.092Z"},"accession":"S-EPMC10850656","cross_references":{"pubmed":["37788895"],"doi":["10.1136/gutjnl-2023-329524"]}}