biostudies-literatureMauri GFondazione Oncologia Niguarda OnlusFondazione Regionale Ricerca Biomedica Regione Lombardiae885-e889https://www.ebi.ac.uk/biostudies/studies/S-EPMC10850832biostudies-literatureUnknown13(e3)<h4>Objectives</h4>Early-onset colorectal cancer (EO-CRC) incidence is increasing, raising a clinical challenge. Clinicians tend to treat EO-CRC patients with more intensive regimens despite the lack of survival benefits, based on an age-related bias. Limited evidence is available regarding treatment-related toxicities in this peculiar subset of patients.<h4>Methods</h4>We performed a literature search in MEDLINE/PubMed, EMBASE and Scopus, looking for reporting of nausea, vomiting and diarrhoea occurring in patients with EO-CRC, defined by age lower than 50 years old at initial diagnosis, while receiving anticancer treatment.<h4>Results</h4>2318 records were screened and 9 full-text articles were considered eligible for inclusion for a total of 59 783 patients (of whom 8681 EO-CRC patientsBMJ supportive & palliative careYoung-onset colorectal cancer: treatment-related nausea, vomiting and diarrhoea.PMC10850832CP 12/2018Siena SArtale SSartore-Bianchi ABonazzina EPedrazzoli PMariano SSerra FMauri GCavestro GMPedrani MGhezzi SBencardino KCaccialanza RfalseYoung-onset colorectal cancer: treatment-related nausea, vomiting and diarrhoea.<h4>Objectives</h4>Early-onset colorectal cancer (EO-CRC) incidence is increasing, raising a clinical challenge. Clinicians tend to treat EO-CRC patients with more intensive regimens despite the lack of survival benefits, based on an age-related bias. Limited evidence is available regarding treatment-related toxicities in this peculiar subset of patients.<h4>Methods</h4>We performed a literature search in MEDLINE/PubMed, EMBASE and Scopus, looking for reporting of nausea, vomiting and diarrhoea occurring in patients with EO-CRC, defined by age lower than 50 years old at initial diagnosis, while receiving anticancer treatment.<h4>Results</h4>2318 records were screened and 9 full-text articles were considered eligible for inclusion for a total of 59 783 patients (of whom 8681 EO-CRC patients2024-01-01T00:00:00Z2024 Jan2026-06-12T05:52:52.261Z2026-06-12T03:08:26.868ZS-EPMC108508323734415810.1136/spcare-2023-004203