{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kerlikowske K"],"funding":["Agency for Health Research and Quality","AHRQ HHS","National Cancer Institute","Lake Champlain Cancer Research Organization","NCI NIH HHS","University of Vermont Cancer Center","Breast Cancer Surveillance Consortium","Patient-Centered Outcomes Research Institute"],"pagination":["249-257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10852604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(2)"],"pubmed_abstract":["Background
Examining screening outcomes by breast density for breast magnetic resonance imaging (MRI) with or without mammography could inform discussions about supplemental MRI in women with dense breasts.Methods
We evaluated 52 237 women aged 40-79 years who underwent 2611 screening MRIs alone and 6518 supplemental MRI plus mammography pairs propensity score-matched to 65 810 screening mammograms. Rates per 1000 examinations of interval, advanced, and screen-detected early stage invasive cancers and false-positive recall and biopsy recommendation were estimated by breast density (nondense = almost entirely fatty or scattered fibroglandular densities; dense = heterogeneously/extremely dense) adjusting for registry, examination year, age, race and ethnicity, family history "],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density."],"pmcid":["PMC10852604"],"funding_grant_id":["P01CA154292","R01 HS018366","R01 HS018366-01A1","#032800","U54CA163303","PCS-1504-30370","U54 CA163303","P01 CA154292"],"pubmed_authors":["Su YR","O'Meara ES","Tosteson ANA","Stout NK","Onega T","Wernli K","Zhu W","Sprague BL","Henderson LM","Kerlikowske K","Miglioretti DL"],"additional_accession":[]},"is_claimable":false,"name":"Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density.","description":"Background
Examining screening outcomes by breast density for breast magnetic resonance imaging (MRI) with or without mammography could inform discussions about supplemental MRI in women with dense breasts.Methods
We evaluated 52 237 women aged 40-79 years who underwent 2611 screening MRIs alone and 6518 supplemental MRI plus mammography pairs propensity score-matched to 65 810 screening mammograms. Rates per 1000 examinations of interval, advanced, and screen-detected early stage invasive cancers and false-positive recall and biopsy recommendation were estimated by breast density (nondense = almost entirely fatty or scattered fibroglandular densities; dense = heterogeneously/extremely dense) adjusting for registry, examination year, age, race and ethnicity, family history ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-04T11:11:12.711Z","creation":"2025-04-20T00:45:56.332Z"},"accession":"S-EPMC10852604","cross_references":{"pubmed":["37897090"],"doi":["10.1093/jnci/djad201"]}}