biostudies-literatureChe DNational Natural Science Foundation of Chinae13603https://www.ebi.ac.uk/biostudies/studies/S-EPMC10853572biostudies-literatureUnknown30(2)<h4>Background</h4>Psoriasis is a prevalent, long-term skin condition characterized by inflammation. Keratinocytes (KCs) are important effector cells that release inflammatory factors and chemokines to promote the inflammatory cascade in psoriasis. However, the mechanisms underlying the activation of KCs in psoriasis remain unclear. Livin suppresses apoptotic proteins and directly affects the growth and spread of cancer cells. Livin expression reportedly increases significantly in lesions of patients with psoriasis; however, its specific role in KC activation remains unknown. This study aimed to examine the impact of Livin on KC activation and the subsequent release of inflammatory mediators.<h4>Methods</h4>Immunofluorescence staining, reverse transcription-quantitative polymerase chain reSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.PMC108535728237348581872529Li YHang BChe DWang HLi KWang KfalseLivin expression promotes keratinocyte release of inflammatory mediators in psoriasis.<h4>Background</h4>Psoriasis is a prevalent, long-term skin condition characterized by inflammation. Keratinocytes (KCs) are important effector cells that release inflammatory factors and chemokines to promote the inflammatory cascade in psoriasis. However, the mechanisms underlying the activation of KCs in psoriasis remain unclear. Livin suppresses apoptotic proteins and directly affects the growth and spread of cancer cells. Livin expression reportedly increases significantly in lesions of patients with psoriasis; however, its specific role in KC activation remains unknown. This study aimed to examine the impact of Livin on KC activation and the subsequent release of inflammatory mediators.<h4>Methods</h4>Immunofluorescence staining, reverse transcription-quantitative polymerase chain re2024-01-01T00:00:00Z2024 Feb2026-06-06T21:54:49.508Z2025-04-05T14:51:32.66ZS-EPMC108535723833251310.1111/srt.13603