{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen X"],"funding":["the Project of Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi","National Natural Science Foundation of China","Shanxi Applied Basic Research Program Outstanding Youth Cultivation Project Fund","Shanxi Applied Basic Research Program Science-Youth Technology Research Fund"],"pagination":["e18130"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10853586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(4)"],"pubmed_abstract":["The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating scar formation. However, there has been limited attention given to pectolinarin, a natural flavonoid that may exhibit strong binding affinity to YAP, in the context of scarless healing. In this study, we successfully developed a temperature-sensitive Pluronic@F-127 hydrogel as a platform for delivering pectolinarin to promote scarless wound healing. The bioactive pectolinarin was released fro"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Temperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing."],"pmcid":["PMC10853586"],"funding_grant_id":["2020L0209","82071155","RC2021-02","82271023","82301052","202203021223006","20210302124398","RC2023-01"],"pubmed_authors":["Song K","Liu M","Zhang Y","Hong J","Chen X","Wang X","Song H","Xie Q","Wang J","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Temperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing.","description":"The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating scar formation. However, there has been limited attention given to pectolinarin, a natural flavonoid that may exhibit strong binding affinity to YAP, in the context of scarless healing. In this study, we successfully developed a temperature-sensitive Pluronic@F-127 hydrogel as a platform for delivering pectolinarin to promote scarless wound healing. The bioactive pectolinarin was released fro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-04T13:34:40.754Z","creation":"2025-04-04T13:34:40.754Z"},"accession":"S-EPMC10853586","cross_references":{"pubmed":["38332511"],"doi":["10.1111/jcmm.18130"]}}