biostudies-literatureChen Xthe Project of Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materialsthe Scientific and Technological Innovation Programs of Higher Education Institutions in ShanxiNational Natural Science Foundation of ChinaShanxi Applied Basic Research Program Outstanding Youth Cultivation Project FundShanxi Applied Basic Research Program Science-Youth Technology Research Funde18130https://www.ebi.ac.uk/biostudies/studies/S-EPMC10853586biostudies-literatureUnknown28(4)The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating scar formation. However, there has been limited attention given to pectolinarin, a natural flavonoid that may exhibit strong binding affinity to YAP, in the context of scarless healing. In this study, we successfully developed a temperature-sensitive Pluronic@F-127 hydrogel as a platform for delivering pectolinarin to promote scarless wound healing. The bioactive pectolinarin was released froJournal of cellular and molecular medicineTemperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing.PMC108535862020L020982071155RC2021-02822710238230105220220302122300620210302124398RC2023-01Song KLiu MZhang YHong JChen XWang XSong HXie QWang JZhao JfalseTemperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing.The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating scar formation. However, there has been limited attention given to pectolinarin, a natural flavonoid that may exhibit strong binding affinity to YAP, in the context of scarless healing. In this study, we successfully developed a temperature-sensitive Pluronic@F-127 hydrogel as a platform for delivering pectolinarin to promote scarless wound healing. The bioactive pectolinarin was released fro2024-01-01T00:00:00Z2024 Feb2025-04-04T13:34:40.754Z2025-04-04T13:34:40.754ZS-EPMC108535863833251110.1111/jcmm.18130