{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["National Health and Medical Research Council of Australia","NSERC","National Science and Engineering Research Council of Canada","Royal Adelaide Hospital Florey Fellowship","National Natural Science Foundation of China","University of South Australia","NCI NIH HHS","Guangdong Science and Technology Department","National Breast Cancer Foundation","Canada Research Chair in Functional Proteomics"],"pagination":["1387-1403"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10853802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(3)"],"pubmed_abstract":["While the majority of circRNAs are formed from infrequent back-splicing of exons from protein coding genes, some can be produced at quite high level and in a regulated manner. We describe the regulation, biogenesis and function of circDOCK1(2-27), a large, abundant circular RNA that is highly regulated during epithelial-mesenchymal transition (EMT) and whose formation depends on the epithelial splicing regulator ESRP1. CircDOCK1(2-27) synthesis in epithelial cells represses cell motility both by diverting transcripts from DOCK1 mRNA production to circRNA formation and by direct inhibition of migration by the circRNA. HITS-CLIP analysis and CRISPR-mediated deletions indicate ESRP1 controls circDOCK1(2-27) biosynthesis by binding a GGU-containing repeat region in intron 1 and detaining its s"],"journal":["Nucleic acids research"],"pubmed_title":["ESRP1 controls biogenesis and function of a large abundant multiexon circRNA."],"pmcid":["PMC10853802"],"funding_grant_id":["GNT1118170","GNT1089167","RGPIN-2019-06297","P30 CA008748","2020B1212030004","31900435","2020B1212060018","IN-16-072"],"pubmed_authors":["Dyakov BJA","Patel D","Guo W","Conn VM","Conn SJ","Wu B","Gregory PA","Bert AG","Migault MM","Dredge BK","Toubia J","Goodall GJ","Pillman KA","Liu D","Gingras AC"],"additional_accession":[]},"is_claimable":false,"name":"ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.","description":"While the majority of circRNAs are formed from infrequent back-splicing of exons from protein coding genes, some can be produced at quite high level and in a regulated manner. We describe the regulation, biogenesis and function of circDOCK1(2-27), a large, abundant circular RNA that is highly regulated during epithelial-mesenchymal transition (EMT) and whose formation depends on the epithelial splicing regulator ESRP1. CircDOCK1(2-27) synthesis in epithelial cells represses cell motility both by diverting transcripts from DOCK1 mRNA production to circRNA formation and by direct inhibition of migration by the circRNA. HITS-CLIP analysis and CRISPR-mediated deletions indicate ESRP1 controls circDOCK1(2-27) biosynthesis by binding a GGU-containing repeat region in intron 1 and detaining its s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-05-01T03:23:18.964Z","creation":"2025-04-05T14:51:12.646Z"},"accession":"S-EPMC10853802","cross_references":{"pubmed":["38015468"],"doi":["10.1093/nar/gkad1138"]}}