{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leal Reis I"],"funding":["Fundação para a Ciência e Tecnologia","Prémios Santa Casa Neurociências"],"pagination":["370"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10854557"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used to develop therapeutic products, as they secrete a variety of bioactive molecules that play a pivotal role in tissue regeneration. These factors are released in culture media for producing a conditioned medium (CM). The aforementioned assumptions led to the formulation of equine synovial membrane MSCs (eSM-MSCs)-the cellular pool that naturally regenerates joint tissue-combined with a medium enriched in immu"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept."],"pmcid":["PMC10854557"],"funding_grant_id":["2023.00246.BD","2021.05265.BD","UIDB/00211/2020","SFRH/BD/146689/2019","2022.04501.PTDC","MC-04/17; MC-18-2021"],"pubmed_authors":["Lopes B","Sousa P","Leal Reis I","Briote I","Sousa AC","Rema A","Caseiro AR","Mauricio AC","Branquinho MV","Mendonca CM","Santos JM","Atayde LM","Alvites RD"],"additional_accession":[]},"is_claimable":false,"name":"Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept.","description":"Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used to develop therapeutic products, as they secrete a variety of bioactive molecules that play a pivotal role in tissue regeneration. These factors are released in culture media for producing a conditioned medium (CM). The aforementioned assumptions led to the formulation of equine synovial membrane MSCs (eSM-MSCs)-the cellular pool that naturally regenerates joint tissue-combined with a medium enriched in immu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-05T14:51:17.416Z","creation":"2025-04-05T14:51:17.416Z"},"accession":"S-EPMC10854557","cross_references":{"pubmed":["38338013"],"doi":["10.3390/ani14030370"]}}