biostudies-literatureUnknown10(1)Klarenberg H<h4>Objectives</h4>To investigate the association between leisure time physical activity (LTPA) and MRI-based diastolic function and the mediating role of metabolic health.<h4>Methods</h4>This cross-sectional analysis comprised 901 participants (46% women, mean age (SD): 56 (6) years (The Netherlands, 2008-2012)). LTPA was assessed via questionnaire, quantified in metabolic equivalent of tasks (METs)-minutes per week and participants underwent abdominal and cardiovascular MRI. Confirmatory factor analysis was used to construct the metabolic load factor. Piecewise structural equation model with adjustments for confounders was used to determine associations between LTPA and diastolic function and the mediating effect of metabolic load.<h4>Results</h4>Significant differences in mitral early/lBMJ open sport & exercise medicinee001778https://www.ebi.ac.uk/biostudies/studies/S-EPMC10860076biostudies-literatureLeisure time physical activity is associated with improved diastolic heart function and is partly mediated by unsupervised quantified metabolic health.PMC10860076Boekholdt SMJukema JWLeiner TJorstad HRosendaal FRFroeling MKlarenberg Hvan der Velde JHPeeters CFde Mutsert RLamb HJDekkers IAStrijkers GJfalseLeisure time physical activity is associated with improved diastolic heart function and is partly mediated by unsupervised quantified metabolic health.<h4>Objectives</h4>To investigate the association between leisure time physical activity (LTPA) and MRI-based diastolic function and the mediating role of metabolic health.<h4>Methods</h4>This cross-sectional analysis comprised 901 participants (46% women, mean age (SD): 56 (6) years (The Netherlands, 2008-2012)). LTPA was assessed via questionnaire, quantified in metabolic equivalent of tasks (METs)-minutes per week and participants underwent abdominal and cardiovascular MRI. Confirmatory factor analysis was used to construct the metabolic load factor. Piecewise structural equation model with adjustments for confounders was used to determine associations between LTPA and diastolic function and the mediating effect of metabolic load.<h4>Results</h4>Significant differences in mitral early/l2024-01-01T00:00:00Z20242026-07-16T00:48:48.452Z2026-07-09T13:09:47.243ZS-EPMC108600763834785610.1136/bmjsem-2023-001778