{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fei C"],"funding":["Beijing Municipal Natural Science Foundation","Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China","Education Department of Inner Mongolia Autonomous Region"],"pagination":["5536-5547"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10860698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease whose standard of care is immunosuppressive treatment with inevitable undesired outcomes. Macrophage is acknowledged to aggravate liver damage, providing a promising AIH therapeutic target. Accordingly, in this study, a kind of curdlan-decorated fullerene nanoparticle (Cur-F) is fabricated to alleviate immune-mediated hepatic injury for treating AIH via reducing macrophage infiltration in a concanavalin A (Con A)-induced AIH mouse model. After intravenous administration, Cur-F primarily distributes in liver tissues, efficiently eliminates the excessive reactive oxygen species, significantly attenuates oxidative stress, and subsequently suppresses the nuclear factor kappa-B-gene binding (NF-κB) signal pathway,"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration."],"pmcid":["PMC10860698"],"funding_grant_id":["52272048","NJZY22722","2222090","2022YFA1205900"],"pubmed_authors":["Peng Y","Li X","Fei C","Liu L","Qi H","Wang C","Han J"],"additional_accession":[]},"is_claimable":false,"name":"Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration.","description":"Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease whose standard of care is immunosuppressive treatment with inevitable undesired outcomes. Macrophage is acknowledged to aggravate liver damage, providing a promising AIH therapeutic target. Accordingly, in this study, a kind of curdlan-decorated fullerene nanoparticle (Cur-F) is fabricated to alleviate immune-mediated hepatic injury for treating AIH via reducing macrophage infiltration in a concanavalin A (Con A)-induced AIH mouse model. After intravenous administration, Cur-F primarily distributes in liver tissues, efficiently eliminates the excessive reactive oxygen species, significantly attenuates oxidative stress, and subsequently suppresses the nuclear factor kappa-B-gene binding (NF-κB) signal pathway,","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-03T23:36:28.938Z","creation":"2025-04-03T23:36:28.938Z"},"accession":"S-EPMC10860698","cross_references":{"pubmed":["38267397"],"doi":["10.1021/acsami.3c16168"]}}