{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Wu LH"],"pubmed_abstract":["The β3-adrenoceptor is a protein responsible for regulating the body's response to the neurotransmitter adrenaline and the hormone norepinephrine. It is critical in various physiological processes, including metabolism, thermogenesis, and cardiovascular function. Recently, researchers have discovered that the β3-adrenoceptor is also implicated in tumor progression and metastasis. Infections caused by <i>Salmonella</i> can lead to gastroenteritis; however, intriguingly, <i>Salmonella</i> is associated with tumor inhibition. In this study, <i>Salmonella</i> treatment resulted in the downregulation of β3-adrenoceptor expression and a decrease in the phosphorylation of the Protein Kinase-B (AKT)/Mammalian Target of Rapamycin (mTOR) pathway, as observed through immunoblotting in a dose-dependent manner. Notably, <i>Salmonella</i> treatment significantly reduced tumor cell migration, as demonstrated by wound healing and Transwell assays. Moreover, tumor-bearing mice that received <i>Salmonella</i>-pre-treated tumor cells exhibited improved survival rates compared to those injected with tumor cells without prior <i>Salmonella</i> treatment. The observed anti-metastatic effect in this study suggests that <i>Salmonella</i> treatment could hold promise as a potential therapeutic approach to combat tumor metastasis. Further research is warranted to explore its full therapeutic potential."],"journal":["Journal of Cancer"],"pagination":["1203-1212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10861817"],"repository":["biostudies-literature"],"pubmed_title":["<i>Salmonella-</i>induced inhibition of β3-adrenoceptor expression in tumors and reduces tumor metastasis."],"pmcid":["PMC10861817"],"pubmed_authors":["Wu LH","Lee CH","Huang YT","Lin CY"],"additional_accession":[]},"is_claimable":false,"name":"<i>Salmonella-</i>induced inhibition of β3-adrenoceptor expression in tumors and reduces tumor metastasis.","description":"The β3-adrenoceptor is a protein responsible for regulating the body's response to the neurotransmitter adrenaline and the hormone norepinephrine. It is critical in various physiological processes, including metabolism, thermogenesis, and cardiovascular function. Recently, researchers have discovered that the β3-adrenoceptor is also implicated in tumor progression and metastasis. Infections caused by <i>Salmonella</i> can lead to gastroenteritis; however, intriguingly, <i>Salmonella</i> is associated with tumor inhibition. In this study, <i>Salmonella</i> treatment resulted in the downregulation of β3-adrenoceptor expression and a decrease in the phosphorylation of the Protein Kinase-B (AKT)/Mammalian Target of Rapamycin (mTOR) pathway, as observed through immunoblotting in a dose-dependent manner. Notably, <i>Salmonella</i> treatment significantly reduced tumor cell migration, as demonstrated by wound healing and Transwell assays. Moreover, tumor-bearing mice that received <i>Salmonella</i>-pre-treated tumor cells exhibited improved survival rates compared to those injected with tumor cells without prior <i>Salmonella</i> treatment. The observed anti-metastatic effect in this study suggests that <i>Salmonella</i> treatment could hold promise as a potential therapeutic approach to combat tumor metastasis. Further research is warranted to explore its full therapeutic potential.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2024-12-04T03:25:52.723Z","creation":"2024-12-04T03:25:52.723Z"},"accession":"S-EPMC10861817","cross_references":{"pubmed":["38356700"],"doi":["10.7150/jca.92024"]}}