{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yu H"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pubmed_abstract":["The adaptive T cell response is accompanied by continuous rewiring of the T cell's electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcom"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.01.31.578284"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10862906"],"repository":["biostudies-literature"],"pubmed_title":["Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity."],"pmcid":["PMC10862906"],"funding_grant_id":["P30 CA016056","R01 AI099300","R01 AI089830"],"pubmed_authors":["Higgins M","Zheng Y","Chang KY","Blosser L","Mitchell-Flack M","Nishio H","Lebid A","Tam A","Vignali PDA","Yu H","Barbi J","Li Z","Huang CT","Zhang X","Fu J","Drake CG","Pardoll DM"],"additional_accession":[]},"is_claimable":false,"name":"Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity.","description":"The adaptive T cell response is accompanied by continuous rewiring of the T cell's electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcom","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-08T15:59:57.897Z","creation":"2025-04-06T12:31:07.572Z"},"accession":"S-EPMC10862906","cross_references":{"pubmed":["38352414"],"doi":["10.1101/2024.01.31.578284"]}}