biostudies-literatureUnknownYu HNIAID NIH HHSNCI NIH HHSThe adaptive T cell response is accompanied by continuous rewiring of the T cell's electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcombioRxiv : the preprint server for biology2024.01.31.578284https://www.ebi.ac.uk/biostudies/studies/S-EPMC10862906biostudies-literatureNeurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity.PMC10862906P30 CA016056R01 AI099300R01 AI089830Higgins MZheng YChang KYBlosser LMitchell-Flack MNishio HLebid ATam AVignali PDAYu HBarbi JLi ZHuang CTZhang XFu JDrake CGPardoll DMfalseNeurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity.The adaptive T cell response is accompanied by continuous rewiring of the T cell's electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcom2024-01-01T00:00:00Z2024 Aug2026-04-08T15:59:57.897Z2025-04-06T12:31:07.572ZS-EPMC108629063835241410.1101/2024.01.31.578284