biostudies-literatureArai YNIDCR NIH HHSNational Institute of Dental and Craniofacial Research29-38https://www.ebi.ac.uk/biostudies/studies/S-EPMC10864015biostudies-literatureUnknown26 Suppl 1Tooth eruption is a pivotal milestone for children's growth and development. This process involves with the formation of the tooth root, the periodontal ligament (PDL) and the alveolar bone, as the tooth crown penetrates the bone and gingiva to enter the oral cavity. This review aims to outline current knowledge of the adverse dental effects of antiresorptive medications. Recently, paediatric indications for antiresorptive medications, such as bisphosphonates (BPs), have emerged, and these agents are increasingly used in children and adolescents to cure pathological bone resorption associated with bone diseases and cancers. Since tooth eruption is accompanied by osteoclastic bone resorption, it is expected that the administration of antiresorptive medications during this period affects tooOrthodontics & craniofacial researchEffects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.PMC10864015R01 DE030630R01 DE026666R01 DE029181Ono NEnglish JDOno WArai YfalseEffects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.Tooth eruption is a pivotal milestone for children's growth and development. This process involves with the formation of the tooth root, the periodontal ligament (PDL) and the alveolar bone, as the tooth crown penetrates the bone and gingiva to enter the oral cavity. This review aims to outline current knowledge of the adverse dental effects of antiresorptive medications. Recently, paediatric indications for antiresorptive medications, such as bisphosphonates (BPs), have emerged, and these agents are increasingly used in children and adolescents to cure pathological bone resorption associated with bone diseases and cancers. Since tooth eruption is accompanied by osteoclastic bone resorption, it is expected that the administration of antiresorptive medications during this period affects too2023-01-01T00:00:00Z2023 Dec2025-05-18T11:06:10.871Z2025-02-18T23:14:25.704ZS-EPMC108640153671497010.1111/ocr.12637