biostudies-literatureSaleh MGNICHD NIH HHSNIBIB NIH HHSNCCIH NIH HHSNIDA NIH HHSNIHNIH HHS1314-1322https://www.ebi.ac.uk/biostudies/studies/S-EPMC10865745biostudies-literatureUnknown91(4)<h4>Purpose</h4>To demonstrate J-difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher-Garwood-edited spectroscopy (HERMES).<h4>Methods</h4>Density-matrix simulations of HERMES (TE 80 ms) and 1D J-resolved (TE 31-229 ms) of glutamate (Glu), glutamine (Gln), γ-aminobutyric acid (GABA), and glutathione (GSH) were performed. HERMES comprised four sub-experiments with editing pulses applied as follows: (A) 1.9/4.56 ppm simultaneously (ON_GABA /ON_GSH ); (B) 1.9 ppm only (ON_GABA /OFF_GSH ); (C) 4.56 ppm only (OFF_GABA /ON_GSH ); and (D) 7.5 ppm (OFF_GABA /OFF_GSH ). Phantom HERMES and 1D J-resolved experiments of Glu were performed. Finally, in vivo HERMES (20-ms editing pulses) anMagnetic resonance in medicineGlutamate measurements using edited MRS.PMC10865745R01 EB016089U01 DA041117P50 HD105354R01EB016089R00DA051315P50 HD103538U01DA041117K99 DA051315R21 AT010736U01DA041134U01 DA041134R01EB023963R21 DA047673R21DA047673P41EB031771P41 EB031771R01 EB023963R00 DA051315Saleh MGChang LCunningham ECloak CRenshaw PFEdden RAEZollner HJPrescot ASubramaniam PYurgelun-Todd DErnst TRoberts TPLfalseGlutamate measurements using edited MRS.<h4>Purpose</h4>To demonstrate J-difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher-Garwood-edited spectroscopy (HERMES).<h4>Methods</h4>Density-matrix simulations of HERMES (TE 80 ms) and 1D J-resolved (TE 31-229 ms) of glutamate (Glu), glutamine (Gln), γ-aminobutyric acid (GABA), and glutathione (GSH) were performed. HERMES comprised four sub-experiments with editing pulses applied as follows: (A) 1.9/4.56 ppm simultaneously (ON_GABA /ON_GSH ); (B) 1.9 ppm only (ON_GABA /OFF_GSH ); (C) 4.56 ppm only (OFF_GABA /ON_GSH ); and (D) 7.5 ppm (OFF_GABA /OFF_GSH ). Phantom HERMES and 1D J-resolved experiments of Glu were performed. Finally, in vivo HERMES (20-ms editing pulses) an2024-01-01T00:00:00Z2024 Apr2025-06-25T03:04:27.44Z2025-06-25T03:04:27.44ZS-EPMC108657453804472310.1002/mrm.29929