{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Di Modugno F"],"funding":["Associazione Italiana per la Ricerca sul Cancro","Ministero della Salute","ACC","Accident Compensation Corporation","NCI NIH HHS","Cancer Research Institute","Fondazione Italiana per la Ricerca sul Cancro Airc","Chulabhorn Research Institute"],"pagination":["105003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10869748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["101"],"pubmed_abstract":["<h4>Background</h4>Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, producing the epithelial hMENA<sup>11a</sup> linked to favorable prognosis in early NSCLC, and the mesenchymal hMENAΔv6 found in invasive cancer cells and pro-tumoral cancer-associated fibroblasts (CAFs). This study investigates how hMENA isoforms in tumor cells and CAFs relate to TLS presence, localization and impact on patient outcomes and ICB response.<h4>Methods</h4>Methods involved RNA-SEQ on NSCLC cells with depleted hMENA isoforms. A retrospective observational study assessed tissues from surgically treated N0 patients with NSCLC, using immun"],"journal":["EBioMedicine"],"pubmed_title":["Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer."],"pmcid":["PMC10869748"],"funding_grant_id":["R37 CA247676","IG 19822","RCR-2019-23669120"],"pubmed_authors":["Xiong J","Nistico P","Palermo B","Cappuzzo F","Vincent BG","Warren S","Visca P","D'Ambrosio L","Goeman F","De Nicola F","Panetta M","Facciolo F","Balzano V","Wheeler N","Melchionna R","D'Andrea D","Gallo E","Bortone DS","Di Carlo A","Campo G","Tripodo C","Sperduti I","Antoniani B","Lambrechts D","Carpano S","Belmonte B","Frige G","Di Modugno F","Gallina F","Spada S","Morello G"],"additional_accession":[]},"is_claimable":false,"name":"Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer.","description":"<h4>Background</h4>Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, producing the epithelial hMENA<sup>11a</sup> linked to favorable prognosis in early NSCLC, and the mesenchymal hMENAΔv6 found in invasive cancer cells and pro-tumoral cancer-associated fibroblasts (CAFs). This study investigates how hMENA isoforms in tumor cells and CAFs relate to TLS presence, localization and impact on patient outcomes and ICB response.<h4>Methods</h4>Methods involved RNA-SEQ on NSCLC cells with depleted hMENA isoforms. A retrospective observational study assessed tissues from surgically treated N0 patients with NSCLC, using immun","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-12T05:50:38.705Z","creation":"2025-04-05T09:07:58.87Z"},"accession":"S-EPMC10869748","cross_references":{"pubmed":["38340557"],"doi":["10.1016/j.ebiom.2024.105003"]}}