{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bao Q"],"funding":["Guang'an Science and Technology Bureau","Mingfei Yang was awarded the leading talent of the 2020 Kunlun Talents of Qinghai Province High-End Innovation and Entrepreneurship Talent Project-Cultivate Leading Talents"],"pagination":["e3431"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10869883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["<h4>Background</h4>Intravenous thrombolysis (IVT), which is safe and effective, is the first-line therapy for acute ischemic stroke (AIS). However, its benefit for AIS patients with pre-stroke disability (PSD) is controversial.<h4>Objective</h4>We determined the association of PSD with the safety and efficacy of IVT among patients with AIS.<h4>Methods</h4>We searched PubMed, Embase, and the Cochrane Library from inception to May 23, 2022. The articles focusing on outcomes of AIS patients with PSD receiving IVT were retrieved. We used the random-effects model to pool outcomes including mortality, 24 h NIHSS improvement, symptomatic intracerebral hemorrhage (sICH), favorable functional outcome (FFO), the favorable outcome, and mortality prevalence.<h4>Results</h4>Ten studies (including 245,7"],"journal":["Brain and behavior"],"pubmed_title":["Intravenous thrombolysis in acute ischemic stroke patients with pre-stroke disability: A systematic review and meta-analysis."],"pmcid":["PMC10869883"],"funding_grant_id":["2023zdxjh03"],"pubmed_authors":["Li Y","Yang M","Yang P","Chen S","Bao Q","Zhang Q","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Intravenous thrombolysis in acute ischemic stroke patients with pre-stroke disability: A systematic review and meta-analysis.","description":"<h4>Background</h4>Intravenous thrombolysis (IVT), which is safe and effective, is the first-line therapy for acute ischemic stroke (AIS). However, its benefit for AIS patients with pre-stroke disability (PSD) is controversial.<h4>Objective</h4>We determined the association of PSD with the safety and efficacy of IVT among patients with AIS.<h4>Methods</h4>We searched PubMed, Embase, and the Cochrane Library from inception to May 23, 2022. The articles focusing on outcomes of AIS patients with PSD receiving IVT were retrieved. We used the random-effects model to pool outcomes including mortality, 24 h NIHSS improvement, symptomatic intracerebral hemorrhage (sICH), favorable functional outcome (FFO), the favorable outcome, and mortality prevalence.<h4>Results</h4>Ten studies (including 245,7","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-20T04:02:29.56Z","creation":"2025-04-20T04:02:29.56Z"},"accession":"S-EPMC10869883","cross_references":{"pubmed":["38361315"],"doi":["10.1002/brb3.3431"]}}