{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang B"],"funding":["Chongqing Natural Science Foundation Innovation and Development Joint Fund","Postdoctoral Science Foundation of Chongqing","Science and Technology Research Project of Chongqing Municipal Education Commission","Natural Science Foundation of Chongqing","Graduate Tutor Team Construction Project of Chongqing","National Natural Science Foundation of China","Chongqing Talents-Exceptional Young Talents Project","Future Medical Youth Innovation Team Project of Chongqing Medical University","Top Graduate Talent Cultivation Program of Chongqing Medical University"],"pagination":["34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10870583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal mediators in cancers. However, the role of circRNAs in ccRCC progression remains elusive.<h4>Methods</h4>The differentially expressed circRNAs in 4 paired human ccRCC and adjacent noncancerous tissues ccRCC were screened using circRNA microarrays and the candidate target was selected based on circRNA expression level using weighted gene correlation network analysis (WGCNA) and the gene expression omnibus (GEO) database. CircPDHK1 expression in ccRCC and adjacent noncancerous tissues (n = 148) were evaluated along with clinically relevant information. RT-qPCR, RNase R dig"],"journal":["Molecular cancer"],"pubmed_title":["A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway."],"pmcid":["PMC10870583"],"funding_grant_id":["82373001","CSTC2020JCYJ-MSXMX0337","W0042","KJZD-K202100405","CSTB2022NSCQ-LZX0043","CQYC202005044","CSTC2020JCYJ-MSXMX0022","CQMUDSTD202210","CSTB2022NSCQ-BHX0707","BJRC202105"],"pubmed_authors":["Pan X","Ma Q","Li H","Zhang D","Wang C","Ning H","Yang F","Liang C","Li W","Liu Y","Ran A","Ren J","Zhang Y","Wang S","Ran L","Wang X","Wang Y","Huang B","Wei L","Xiao B","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway.","description":"<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal mediators in cancers. However, the role of circRNAs in ccRCC progression remains elusive.<h4>Methods</h4>The differentially expressed circRNAs in 4 paired human ccRCC and adjacent noncancerous tissues ccRCC were screened using circRNA microarrays and the candidate target was selected based on circRNA expression level using weighted gene correlation network analysis (WGCNA) and the gene expression omnibus (GEO) database. CircPDHK1 expression in ccRCC and adjacent noncancerous tissues (n = 148) were evaluated along with clinically relevant information. RT-qPCR, RNase R dig","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-12T08:52:29.938Z","creation":"2024-11-09T07:41:57.562Z"},"accession":"S-EPMC10870583","cross_references":{"pubmed":["38360682"],"doi":["10.1186/s12943-024-01940-0"]}}