{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Talih S"],"funding":["NIDA NIH HHS","National Institutes of Health","National Institute on Drug Abuse"],"pagination":["111052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10872307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["254"],"pubmed_abstract":["<h4>Background</h4>Nicotine form (freebase/protonated) and nicotine flux (rate at which nicotine is emitted) are two factors that can affect the dose of nicotine inhaled by individuals using electronic nicotine delivery systems (ENDS) because they can influence puffing behavior. The nicotine dose for each puff also is directly proportional to nicotine flux (i.e., dose/puff=nicotine flux*puff duration). This study examines the effect of nicotine form and flux on puffing parameters and mouth-level nicotine exposure.<h4>Methods</h4>Thirty-two dual ENDS and combustible cigarette participants completed five visits that differed by nicotine form (freebase or protonated) and nicotine flux (14 or 35µg/sec); a zero-nicotine condition was a negative control. Participants used a Subox Mini C ENDS, po"],"journal":["Drug and alcohol dependence"],"pubmed_title":["Influence of nicotine form and nicotine flux on puffing behavior and mouth-level exposure to nicotine from electronic nicotine delivery systems."],"pmcid":["PMC10872307"],"funding_grant_id":["R01 DA052565","R01DA052565","U54DA036105","U54 DA036105"],"pubmed_authors":["El-Hage R","Talih S","Hanna E","Saliba N","El-Hellani A","Shihadeh A","Talih F","Baldassari S","Karaoghlanian N","Elbejjani M","Salam S","Eissenberg T","Salman R"],"additional_accession":[]},"is_claimable":false,"name":"Influence of nicotine form and nicotine flux on puffing behavior and mouth-level exposure to nicotine from electronic nicotine delivery systems.","description":"<h4>Background</h4>Nicotine form (freebase/protonated) and nicotine flux (rate at which nicotine is emitted) are two factors that can affect the dose of nicotine inhaled by individuals using electronic nicotine delivery systems (ENDS) because they can influence puffing behavior. The nicotine dose for each puff also is directly proportional to nicotine flux (i.e., dose/puff=nicotine flux*puff duration). This study examines the effect of nicotine form and flux on puffing parameters and mouth-level nicotine exposure.<h4>Methods</h4>Thirty-two dual ENDS and combustible cigarette participants completed five visits that differed by nicotine form (freebase or protonated) and nicotine flux (14 or 35µg/sec); a zero-nicotine condition was a negative control. Participants used a Subox Mini C ENDS, po","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-01T18:04:41.191Z","creation":"2026-05-19T03:07:10.339Z"},"accession":"S-EPMC10872307","cross_references":{"pubmed":["38103538"],"doi":["10.1016/j.drugalcdep.2023.111052"]}}